Psychosocial stress and asthma morbidity

被引:108
作者
Yonas, Michael A. [2 ,3 ]
Lange, Nancy E. [4 ]
Celedon, Juan C. [1 ,4 ,5 ]
机构
[1] Brigham & Womens Hosp, Channing Lab, Div Pulm & Crit Care Med, Dept Med, Boston, MA 02115 USA
[2] Univ Pittsburgh, Dept Family Med, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Pediat, Pittsburgh, PA 15260 USA
[4] Univ Pittsburgh, Childrens Hosp Pittsburgh, Div Pediat Pulm Med Allergy & Immunol, Med Ctr, Pittsburgh, PA 15213 USA
[5] Harvard Univ, Sch Med, Boston, MA USA
关键词
allergy; asthma; community; cytokines; maternal; psychosocial; stress; violence; CHILDHOOD ASTHMA; SOCIOECONOMIC-STATUS; COMMUNITY VIOLENCE; SOCIAL STRESS; HEALTH; EXPOSURE; CHILDREN; INTERVENTION; ASSOCIATIONS; ENVIRONMENT;
D O I
10.1097/ACI.0b013e32835090c9
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of review The objective of this review is to provide an overview and discussion of recent epidemiologic and mechanistic studies of stress in relation to asthma incidence and morbidity. Recent findings Recent findings suggest that stress, whether at the individual (i.e. epigenetics, perceived stress), family (i.e. prenatal maternal stress, early-life exposure, or intimate partner violence) or community (i.e. neighborhood violence; neighborhood disadvantage) level, influences asthma and asthma morbidity. Key recent findings regarding how psychosocial stress may influence asthma through Posttraumatic Stress Disorder, prenatal and postnatal maternal/caregiver stress, and community violence and deprivation are highlighted. Summary New research illustrates the need to further examine, characterize, and address the influence of social and environmental factors (i.e. psychological stress) on asthma. Further, research and innovative methodologies are needed to characterize the relationship and pathways associated with stress at multiple levels to more fully understand and address asthma morbidity, and to design potential interventions, especially to address persistent disparities in asthma in ethnic minorities and economically disadvantaged communities.
引用
收藏
页码:202 / 210
页数:9
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