Unfolding the role of stress response signaling in endocrine resistant breast cancers

被引：26
作者：
Clarke, Robert [1 ]
Cook, Katherine L. [1 ]
机构：
[1] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Oncol, W401 Res Bldg,3970 Reservoir Rd NW, Washington, DC 20057 USA
来源：
FRONTIERS IN ONCOLOGY | 2015年 / 5卷
关键词：
unfolded protein response; glucose regulated protein 78; X-box binding protein 1; estrogen receptor-alpha; tamoxifen; ICI 182,780; antiestrogen resistant breast cancer; ENDOPLASMIC-RETICULUM STRESS; ESTROGEN-RECEPTOR-ALPHA; TO-MESENCHYMAL TRANSITION; BOX BINDING PROTEIN-1; ANTIESTROGEN RESPONSIVENESS; DOWN-REGULATOR; CELL-DEATH; KAPPA-B; AUTOPHAGY; GRP78;
D O I：
10.3389/fonc.2015.00140
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.
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页数：10
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共 91 条
  • [21] Heat shock 70 kDa protein 5/glucose-regulated protein 78 "AMP"ing up autophagy
    Cook, Katherine L.
    Clarke, Robert
    [J]. AUTOPHAGY, 2012, 8 (12) : 1827 - 1829
  • [22] Glucose-Regulated Protein 78 Controls Cross-talk between Apoptosis and Autophagy to Determine Antiestrogen Responsiveness
    Cook, Katherine L.
    Shajahan, Ayesha N.
    Waerri, Anni
    Jin, Lu
    Hilakivi-Clarke, Leena A.
    Clarke, Robert
    [J]. CANCER RESEARCH, 2012, 72 (13) : 3337 - 3349
  • [23] Cook KL, 2011, EXPERT REV ANTICANC, V11, P1283, DOI [10.1586/ERA.11.111, 10.1586/era.11.111]
  • [24] Angiotensin-(1-7) Reduces Fibrosis in Orthotopic Breast Tumors
    Cook, Katherine L.
    Metheny-Barlow, Linda J.
    Tallant, E. Ann
    Gallagher, Patricia E.
    [J]. CANCER RESEARCH, 2010, 70 (21) : 8319 - 8328
  • [25] Co-Inhibition of BCL-W and BCL2 Restores Antiestrogen Sensitivity through BECN1 and Promotes an Autophagy-Associated Necrosis
    Crawford, Anatasha C.
    Riggins, Rebecca B.
    Shajahan, Ayesha N.
    Zwart, Alan
    Clarke, Robert
    [J]. PLOS ONE, 2010, 5 (01):
  • [26] Expression and splicing of the unfolded protein response gene XBP-1 are sieniticantly associated with clinical outcome of endocrine-treated breast cancer
    Davies, Michael P. A.
    Barraclough, Dong Liu
    Stewart, Ceri
    Joyce, Kathryn A.
    Eccles, Richard M.
    Barraclough, Roger
    Rudland, Philip S.
    Sibson, David Ross
    [J]. INTERNATIONAL JOURNAL OF CANCER, 2008, 123 (01) : 85 - 88
  • [27] Ligand-independent activation of estrogen receptor α by XBP-1
    Ding, LH
    Yan, JH
    Zhu, JH
    Zhong, HJ
    Lu, QJ
    Wang, ZH
    Huang, CF
    Ye, QN
    [J]. NUCLEIC ACIDS RESEARCH, 2003, 31 (18) : 5266 - 5274
  • [28] Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
    Diop-Frimpong, Benjamin
    Chauhan, Vikash P.
    Krane, Stephen
    Boucher, Yves
    Jain, Rakesh K.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (07) : 2909 - 2914
  • [29] Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor anglogenesis in transgene-induced mammary tumor development
    Dong, Dezheng
    Ni, Min
    Li, Jianze
    Xiong, Shigang
    Ye, Wei
    Virrey, Jenilyn J.
    Mao, Changhui
    Ye, Risheng
    Wang, Miao
    Pen, Ligaya
    Dubeau, Louis
    Groshen, Susan
    Hofman, Florence M.
    Lee, Amy S.
    [J]. CANCER RESEARCH, 2008, 68 (02) : 498 - 505
  • [30] A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis
    Dong, Dezheng
    Stapleton, Christopher
    Luo, Biquan
    Xiong, Shigang
    Ye, Wei
    Zhang, Yi
    Jhaveri, Niyati
    Zhu, Genyuan
    Ye, Risheng
    Liu, Zhi
    Bruhn, Kevin W.
    Craft, Noah
    Groshen, Susan
    Hofman, Florence M.
    Lee, Amy S.
    [J]. CANCER RESEARCH, 2011, 71 (08) : 2848 - 2857
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