Unfolding the role of stress response signaling in endocrine resistant breast cancers

被引：27

作者：

Clarke, Robert ^{[1
]}

Cook, Katherine L. ^{[1
]}

机构：

[1] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Oncol, W401 Res Bldg,3970 Reservoir Rd NW, Washington, DC 20057 USA

来源：

FRONTIERS IN ONCOLOGY | 2015年 / 5卷

关键词：

unfolded protein response; glucose regulated protein 78; X-box binding protein 1; estrogen receptor-alpha; tamoxifen; ICI 182,780; antiestrogen resistant breast cancer; ENDOPLASMIC-RETICULUM STRESS; ESTROGEN-RECEPTOR-ALPHA; TO-MESENCHYMAL TRANSITION; BOX BINDING PROTEIN-1; ANTIESTROGEN RESPONSIVENESS; DOWN-REGULATOR; CELL-DEATH; KAPPA-B; AUTOPHAGY; GRP78;

D O I：

10.3389/fonc.2015.00140

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.

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页数：10

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