Unfolding the role of stress response signaling in endocrine resistant breast cancers

被引：26
作者：
Clarke, Robert [1 ]
Cook, Katherine L. [1 ]
机构：
[1] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Oncol, W401 Res Bldg,3970 Reservoir Rd NW, Washington, DC 20057 USA
来源：
FRONTIERS IN ONCOLOGY | 2015年 / 5卷
关键词：
unfolded protein response; glucose regulated protein 78; X-box binding protein 1; estrogen receptor-alpha; tamoxifen; ICI 182,780; antiestrogen resistant breast cancer; ENDOPLASMIC-RETICULUM STRESS; ESTROGEN-RECEPTOR-ALPHA; TO-MESENCHYMAL TRANSITION; BOX BINDING PROTEIN-1; ANTIESTROGEN RESPONSIVENESS; DOWN-REGULATOR; CELL-DEATH; KAPPA-B; AUTOPHAGY; GRP78;
D O I：
10.3389/fonc.2015.00140
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The unfolded protein response (UPR) is an ancient stress response that enables a cell to manage the energetic stress that accompanies protein folding. There has been a significant recent increase in our understanding of the UPR, how it integrates physiological processes within cells, and how this integration can affect cancer cells and cell fate decisions. Recent publications have highlighted the role of UPR signaling components on mediating various cell survival pathways, cellular metabolism and bioenergenics, and autophagy. We address the role of UPR on mediating endocrine therapy resistance and estrogen receptor-positive breast cancer cell survival.
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页数：10
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共 91 条
  • [1] Estrogen receptor mutations and their role in breast cancer progression
    Alluri, Prasanna G.
    Speers, Corey
    Chinnaiyan, Arul M.
    [J]. BREAST CANCER RESEARCH, 2014, 16 (06)
  • [2] Relationships of ESR1 and XBP1 expression in human breast carcinoma and stromal cells isolated by laser capture microdissection compared to intact breast cancer tissue
    Andres, Sarah A.
    Wittliff, James L.
    [J]. ENDOCRINE, 2011, 40 (02) : 212 - 221
  • [3] Anticipatory estrogen activation of the unfolded protein response is linked to cell proliferation and poor survival in estrogen receptor α-positive breast cancer
    Andruska, N.
    Zheng, X.
    Yang, X.
    Helferich, W. G.
    Shapiro, D. J.
    [J]. ONCOGENE, 2015, 34 (29) : 3760 - 3769
  • [4] [Anonymous], INT J CELL BIOL, DOI 10.1155/2010/930509
  • [5] [Anonymous], 2014, RECEPTORS CLIN INVES
  • [6] Everolimus in Postmenopausal Hormone-Receptor-Positive Advanced Breast Cancer
    Baselga, Jose
    Campone, Mario
    Piccart, Martine
    Burris, Howard A., III
    Rugo, Hope S.
    Sahmoud, Tarek
    Noguchi, Shinzaburo
    Gnant, Michael
    Pritchard, Kathleen I.
    Lebrun, Fabienne
    Beck, J. Thaddeus
    Ito, Yoshinori
    Yardley, Denise
    Deleu, Ines
    Perez, Alejandra
    Bachelot, Thomas
    Vittori, Luc
    Xu, Zhiying
    Mukhopadhyay, Pabak
    Lebwohl, David
    Hortobagyi, Gabriel N.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (06) : 520 - 529
  • [7] Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
    Bursch, W
    Ellinger, A
    Kienzl, H
    Torok, L
    Pandey, S
    Sikorska, M
    Walker, R
    Hermann, RS
    [J]. CARCINOGENESIS, 1996, 17 (08) : 1595 - 1607
  • [8] Glucose-regulated protein 78 (GRP78) regulates colon cancer metastasis through EMT biomarkers and the NRF-2/HO-1 pathway
    Chang, Yu-Jia
    Chen, Wei-Yu
    Huang, Chien-Yu
    Liu, Hui-Hsiung
    Wei, Po-Li
    [J]. TUMOR BIOLOGY, 2015, 36 (03) : 1859 - 1869
  • [9] Mathematical models of the transitions between endocrine therapy responsive and resistant states in breast cancer
    Chen, Chun
    Baumann, William T.
    Xing, Jianhua
    Xu, Lingling
    Clarke, Robert
    Tyson, John J.
    [J]. JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2014, 11 (96)
  • [10] Modeling the estrogen receptor to growth factor receptor signaling switch in human breast cancer cells
    Chen, Chun
    Baumann, William T.
    Clarke, Robert
    Tyson, John J.
    [J]. FEBS LETTERS, 2013, 587 (20) : 3327 - 3334
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