Pandemic Preparedness: Developing Vaccines and Therapeutic Antibodies For COVID-19

被引：69

作者：

Sempowski, Gregory D. ^{[1
,2
]}

Saunders, Kevin O. ^{[3
]}

Acharya, Priyamvada ^{[3
]}

Wiehe, Kevin J. ^{[1
]}

Haynes, Barton F. ^{[1
,4
]}

机构：

[1] Duke Univ, Dept Med, Duke Human Vaccine Inst, Sch Med, Durham, NC 27710 USA

[2] Duke Univ, Sch Med, Dept Pathol, Duke Human Vaccine Inst, Durham, NC 27710 USA

[3] Duke Univ, Sch Med, Dept Surg, Duke Human Vaccine Inst, Durham, NC 27710 USA

[4] Duke Univ, Sch Med, Dept Immunol, Duke Human Vaccine Inst, Durham, NC 27710 USA

来源：

CELL | 2020年 / 181卷 / 07期

关键词：

MONOCLONAL-ANTIBODIES; CORONAVIRUS; IDENTIFICATION; COMBINATION; PROTECTION; PURSUIT; CELLS; SPIKE;

D O I：

10.1016/j.cell.2020.05.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SARS-CoV-2 pandemic that causes COVID-19 respiratory syndrome has caused global public health and economic crises, necessitating rapid development of vaccines and therapeutic countermeasures. The world-wide response to the COVID-19 pandemic has been unprecedented with government, academic, and private partnerships working together to rapidly develop vaccine and antibody countermeasures. Many of the technologies being used are derived from prior government-academic partnerships for response to other emerging infections.

引用

页码：1458 / 1463

页数：6

共 72 条

[1] Antibody-based protection against HIV infection by vectored immunoprophylaxis [J].

Balazs, Alejandro B. ;

Chen, Joyce ;

Hong, Christin M. ;

Rao, Dinesh S. ;

Yang, Lili ;

Baltimore, David .

NATURE, 2012, 481 (7379) :81-U88

[2] The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice [J].

Bao, Linlin ;

Deng, Wei ;

Huang, Baoying ;

Gao, Hong ;

Liu, Jiangning ;

Ren, Lili ;

Wei, Qiang ;

Yu, Pin ;

Xu, Yanfeng ;

Qi, Feifei ;

Qu, Yajin ;

Li, Fengdi ;

Lv, Qi ;

Wang, Wenling ;

Xue, Jing ;

Gong, Shuran ;

Liu, Mingya ;

Wang, Guanpeng ;

Wang, Shunyi ;

Song, Zhiqi ;

Zhao, Linna ;

Liu, Peipei ;

Zhao, Li ;

Ye, Fei ;

Wang, Huijuan ;

Zhou, Weimin ;

Zhu, Na ;

Zhen, Wei ;

Yu, Haisheng ;

Zhang, Xiaojuan ;

Guo, Li ;

Chen, Lan ;

Wang, Conghui ;

Wang, Ying ;

Wang, Xinming ;

Xiao, Yan ;

Sun, Qiangming ;

Liu, Hongqi ;

Zhu, Fanli ;

Ma, Chunxia ;

Yan, Lingmei ;

Yang, Mengli ;

Han, Jun ;

Xu, Wenbo ;

Tan, Wenjie ;

Peng, Xiaozhong ;

Jin, Qi ;

Wu, Guizhen ;

Qin, Chuan .

NATURE, 2020, 583 (7818) :830-+

[3] A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response [J].

Bolles, Meagan ;

Deming, Damon ;

Long, Kristin ;

Agnihothram, Sudhakar ;

Whitmore, Alan ;

Ferris, Martin ;

Funkhouser, William ;

Gralinski, Lisa ;

Totura, Allison ;

Heise, Mark ;

Baric, Ralph S. .

JOURNAL OF VIROLOGY, 2011, 85 (23) :12201-12215

[4]

Brouwer P., 2020, POTENT NEUTRALIZING, DOI [10.1101/2020.05.12.088716, DOI 10.1101/2020.05.12.088716]

[5] A Blueprint for HIV Vaccine Discovery [J].

Burton, Dennis R. ;

Ahmed, Rafi ;

Barouch, Dan H. ;

Butera, Salvatore T. ;

Crotty, Shane ;

Godzik, Adam ;

Kaufmann, Daniel E. ;

McElrath, M. Juliana ;

Nussenzweig, Michel C. ;

Pulendran, Bali ;

Scanlan, Chris N. ;

Schief, William R. ;

Silvestri, Guido ;

Streeck, Hendrik ;

Walker, Bruce D. ;

Walker, Laura M. ;

Ward, Andrew B. ;

Wilson, Ian A. ;

Wyatt, Richard .

CELL HOST & MICROBE, 2012, 12 (04) :396-407

[6] Vaccine innovations for emerging infectious diseases-a symposium report [J].

Cable, Jennifer ;

Srikantiah, Padmini ;

Crowe, James E., Jr. ;

Pulendran, Bali ;

Hill, Adrian ;

Ginsberg, Ann ;

Koff, Wayne ;

Mathew, Anuja ;

Ng, Tony ;

Jansen, Kathrin ;

Glenn, Gregory ;

Permar, Sallie ;

Wilson, Ian ;

Weiner, David B. ;

Weissman, Drew ;

Rappuoli, Rino .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2020, 1462 (01) :14-26

[7] The Global Virome Project [J].

Carroll, Dennis ;

Daszak, Peter ;

Wolfe, Nathan D. ;

Gao, George F. ;

Morel, Carlos M. ;

Morzaria, Subhash ;

Pablos-Mendez, Ariel ;

Tomori, Oyewale ;

Mazet, Jonna A. K. .

SCIENCE, 2018, 359 (6378) :872-874

[8] Next generation antibody drugs: pursuit of the 'high-hanging fruit' [J].

Carter, Paul J. ;

Lazar, Greg A. .

NATURE REVIEWS DRUG DISCOVERY, 2018, 17 (03) :197-223

[9] Broadly neutralizing anti-HIV-1 monoclonal antibodies in the clinic [J].

Caskey, Marina ;

Klein, Florian ;

Nussenzweig, Michel C. .

NATURE MEDICINE, 2019, 25 (04) :547-553

[10] Antibody 10-1074 suppresses viremia in HIV-1-infected individuals [J].

Caskey, Marina ;

Schoofs, Till ;

Gruell, Henning ;

Settler, Allison ;

Karagounis, Theodora ;

Kreider, Edward F. ;

Murrell, Ben ;

Pfeifer, Nico ;

Nogueira, Lilian ;

Oliveira, Thiago Y. ;

Learn, Gerald H. ;

Cohen, Yehuda Z. ;

Lehmann, Clara ;

Gillor, Daniel ;

Shimeliovich, Irma ;

Unson-O'Brien, Cecilia ;

Weiland, Daniela ;

Robles, Alexander ;

Kuemmerle, Tim ;

Wyen, Christoph ;

Levin, Rebeka ;

Witmer-Pack, Maggi ;

Eren, Kemal ;

Ignacio, Caroline ;

Kiss, Szilard ;

West, Anthony P., Jr. ;

Mouquet, Hugo ;

Zingman, Barry S. ;

Gulick, Roy M. ;

Keler, Tibor ;

Bjorkman, Pamela J. ;

Seaman, Michael S. ;

Hahn, Beatrice H. ;

Faetkenheuer, Gerd ;

Schlesinger, Sarah J. ;

Nussenzweig, Michel C. ;

Klein, Florian .

NATURE MEDICINE, 2017, 23 (02) :185-191

← 1 2 3 4 5 6 7 8 →