POLYCYCLIC N-HETEROCYCLIC COMPOUNDS 74: REARRANGEMENT REACTION OF 5-AMINO-1,2-DIHYDROFURO[2,3-c]ISOQUINOLINES WITH α,ω-DIBROMOALKANES AND EVALUATION OF PRODUCT BRONCHODILATOR ACTIVITY

被引：1

作者：

Okuda, Kensuke ^{[1
]}

Yoshida, Masahiko ^{[2
]}

Hirota, Takashi ^{[2
]}

Sasaki, Kenji ^{[2
]}

机构：

[1] Gifu Pharmaceut Univ, Lab Med & Pharmaceut Chem, Gifu 5011196, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 700, Japan

来源：

SYNTHETIC COMMUNICATIONS | 2012年 / 42卷 / 06期

关键词：

Bronchodilator activity; furo[2,3-c]isoquinoline; rearrangement; ring cleavage; spiroheterocycle; CLEAVAGE;

D O I：

10.1080/00397911.2010.532899

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of 5-amino-1,2-dihydrofuro[2,3-c]isoquinolines with 1,2-dibromoethane and 1,3-dibromopropane in the presence of a base afforded 2',3'-dihydrospiro[cyclopropane-1,6'(5'H)-imidazo[2,1-a]isoquinolin]-5'-ones land 3',4'-dihydro-2'H-spiro[cyclopropane-1,7'(6'H)-pyrimido[2,1-a]isoquinolin]-6'-ones, respectively. Certain of the products showed significant bronchodilator activity.

引用

页码：865 / 871

页数：7

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