PGA: power calculator for case-control genetic association analyses

被引：239

作者：

Menashe, Idan ^{[1
]}

Rosenberg, Philip S. ^{[1
]}

Chen, Bingshu E. ^{[1
,2
]}

机构：

[1] NCI, Biostat Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD USA

[2] Concordia Univ, Dept Math & Stat, Montreal, PQ H4B 1R6, Canada

来源：

BMC GENETICS | 2008年 / 9卷 / 1期

关键词：

D O I：

10.1186/1471-2156-9-36

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Statistical power calculations inform the design and interpretation of genetic association studies, but few programs are tailored to case-control studies of single nucleotide polymorphisms (SNPs) in unrelated subjects. Results: We have developed the "Power for Genetic Association analyses" (PGA) package which comprises algorithms and graphical user interfaces for sample size and minimum detectable risk calculations using SNP or haplotype effects under different genetic models and study constrains. The software accounts for linkage disequilibrium and statistical multiple comparisons. The results are presented in graphs or tables and can be printed or exported in standard file formats. Conclusion: PGA is user friendly software that can facilitate decision making for association studies of candidate genes, fine-mapping studies, and whole-genome scans. Stand-alone executable files and a Matlab toolbox are available for download at: http://dceg.cancer.gov/bb/tools/pga.

引用

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