A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-Type Cyclization via Oxidative C-H Activation

被引：36

作者：

Son, Young Wook ^{[2
]}

Kwon, Tae Hui ^{[2
]}

Lee, Jae Kyun ^{[1
]}

Rae, Ae Nim ^{[1
,3
]}

Lee, Jae Yeol ^{[2
]}

Cho, Yong Seo ^{[1
,3
]}

Min, Sun-Joon ^{[1
,3
]}

机构：

[1] Korea Inst Sci & Technol, Ctr NeuroMed, Seoul 136791, South Korea

[2] Kyung Hee Univ, Coll Sci, Dept Chem, Seoul 130701, South Korea

[3] Univ Sci & Technol, Sch Sci, Taejon 305333, South Korea

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 24期

基金：

新加坡国家研究基金会;

关键词：

VESICULAR MONOAMINE TRANSPORTER; CARBON BOND FORMATION; DIHYDROTETRABENAZINE; (+)-ALPHA-DIHYDROTETRABENAZINE; ALLYLSILANES; CATALYST; DISEASE; ESTERS; AGENT; DDQ;

D O I：

10.1021/ol202792q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.

引用

页码：6500 / 6503

页数：4

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