An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis

被引：62
作者：
Oliveira, JS
Sousa, EHS
Basso, LA
Palaci, M
Dietze, R
Santos, DS
Moreira, IS
机构：
[1] Univ Fed Rio Grande do Sul, Dept Mol Biol & Biotechnol, BR-91501970 Porto Alegre, RS, Brazil
[2] Univ Fed Ceara, Dept Quim Organ & Inorgan, BR-60455760 Fortaleza, Ceara, Brazil
[3] Univ Fed Espirito Santo, BR-29040091 Vitoria, ES, Spain
[4] Pontificia Univ Catolica Rio Grande do Sul, Inst Pesquisas Biomed, Fac Farm, BR-90619900 Porto Alegre, RS, Brazil
来源：
CHEMICAL COMMUNICATIONS | 2004年 / 03期
关键词：
D O I：
10.1039/b313592f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The in vitro kinetics of inactivation of both wild-type and I21V InhA enzymes by [Fe-II(CN)(5)(INH)](3-) indicate that this process requires no activation by KatG, and no need for the presence of NADH. This inorganic complex may represent a new class of lead compounds to the development of anti-tubercular agents aiming at inhibition of a validated target.
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收藏
页码：312 / 313
页数：2
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