Fifty Percent Effective Dose of Intranasal Dexmedetomidine Sedation for Transthoracic Echocardiography in Children With Cyanotic and Acyanotic Congenital Heart Disease

被引：11

作者：

Yang, Fei ^{[1
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Li, Shangyingying ^{[1
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Shi, Yuan ^{[1
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Liu, Lu ^{[1
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Ye, Mao ^{[1
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Zhang, Jin ^{[1
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Liu, Hui ^{[1
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Liu, Feng ^{[1
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Yu, Qing ^{[1
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Sun, Mang ^{[1
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Tian, Qin ^{[1
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Tu, Shengfen ^{[1
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机构：

[1] Chongqing Med Univ, Dept Anesthesiol, Childrens Hosp, 136,Second Zhongshan Rd, Chongqing, Peoples R China

[2] Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China

[3] Natl Clin Res Ctr Child Hlth & Disorders Chongqin, Chongqing, Peoples R China

[4] China Int Sci & Technol Cooperat Base Child Dev &, Chongqing, Peoples R China

[5] Chongqing Med Univ, Childrens Hosp, Chongqing, Peoples R China

[6] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Pediat, Chongqing, Peoples R China

来源：

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | 2020年 / 34卷 / 04期

基金：

中国国家自然科学基金;

关键词：

dexmedetomidine; sedation; transthoracic echocardiography; CHLORAL HYDRATE SEDATION; PREMEDICATION; MIDAZOLAM; PHARMACOKINETICS; ANESTHESIA; RESPONSES; INFANTS; ROUTES;

D O I：

10.1053/j.jvca.2019.11.037

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Objectives: To determine the 50% and 95% effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in children with cyanotic and acyanotic congenital heart disease. Design: A prospective, nonrandomized study. Setting: A tertiary care teaching hospital. Participants: Patients younger than 18 months with known or suspected congenital heart disease scheduled for transthoracic echocardiography with sedation. Interventions: Patients were divided into a cyanotic group (blood oxygen saturation <85%) or an acyanotic group (blood oxygen saturation >= 85%). This study used Dixon's up-and-down method sequential allocation design. In both groups, the initial dose of intranasal dexmedetomi- dine was 2 mu g/kg and the gradient of increase or decrease was 0.25 mu g/kg. Measurements and Main Results: The 50% effective dose (95% confidence interval) of intranasal dexmedetomidine sedation for transthoracic echocardiography was 3.2 (2.78-3.55) mu g/kg and 1.9 (1.69-2.06) mu g/kg in the cyanotic and acyanotic groups, respectively. None of the patients experienced significant adverse events. Conclusion: The 50% (95% confidence intervals) effective doses of intranasal dexmedetomidine sedation for transthoracic echocardiography were 3.2 (2.78-3.55) mu g/kg and 1.9 (1.69-2.06) mu g/kg in children with cyanotic and acyanotic congenital heart disease, respectively. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：966 / 971

页数：6

共 33 条

[1] THE POSTANESTHESIA RECOVERY SCORE REVISITED [J].