Rhodium-Catalyzed Decarboxylative Cycloaddition Route to Substituted Anilines

被引：18
|
作者：
Zhang, Kainan [1 ]
Louie, Janis [1 ]
机构：
[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 11期
基金：
美国国家科学基金会;
关键词：
METHYLIDYNETRICOBALT NONACARBONYL; ALKYNE CYCLOTRIMERIZATION; BENZENE-DERIVATIVES; C-N; 1,6-DIYNES; COMPLEX; ISOCYANATES; DIYNES; CONSTRUCTION; PYRIDINES;
D O I：
10.1021/jo200236h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient method for preparing substituted anilines via a Rh-catalyzed [2 + 2 + 2] cycloaddition reaction of diynes and 2-oxazolone was discovered. The initial cycloaddition adducts undergo facile decarboxylation of carbon dioxide to afford aniline products. Reaction conditions are mild, and only 3 mol % Rh catalyst is required. High regioselectivity was observed when an unsymmetrical diyne was used as a starting material.
引用
收藏
页码：4686 / 4691
页数：6
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