A model to estimate the outcome of prostate cancer photodynamic therapy with TOOKAD Soluble WST11

被引：33

作者：

Betrouni, Nacim ^{[1
,2
,3
]}

Lopes, Renaud ^{[1
]}

Puech, Philippe ^{[1
,2
,3
]}

Colin, Pierre ^{[1
,2
,3
]}

Mordon, Serge ^{[1
,2
,3
]}

机构：

[1] INSERM, U703, F-59120 Loos, France

[2] Univ Lille Nord France, F-59000 Lille, France

[3] CHU Lille, F-59000 Lille, France

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2011年 / 56卷 / 15期

关键词：

IN-VIVO; OPTICAL-PROPERTIES; DIFFUSING SOURCES; LIGHT DOSIMETRY; DELIVERY; EDEMA;

D O I：

10.1088/0031-9155/56/15/009

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Interstitial photodynamic therapy is becoming an interesting modality to treat some early stage prostate cancers. A light-sensitive drug is injected to the patient and activated by light using optical fibres inserted inside the prostate. In this work, we were interested in the characterization of the light action model for the WST11 (TookadR (R) Soluble) drug. A retrospective analysis was performed on results from 28 patients enrolled in phase I and II trials with the WST11 drug. A drug dose of 4 mg/kg patient, dose light of 200 J cm(-1) and wavelength of 753 nm were used. Correlation between the illuminated volume and the obtained necrosis, measured at day 7 MR images, was clearly established. This result suggests that photodynamic therapy planning is possible based on this model.

引用

页码：4771 / 4783

页数：13

共 27 条

[1] Optimized interstitial PDT prostate treatment planning with the Cimmino feasibility algorithm
Altschuler, MD
Zhu, TC
Li, J
Hahn, SM
[J]. MEDICAL PHYSICS, 2005, 32 (12) : 3524 - 3536
[2] Photodynamic therapy for focal ablation of the prostate
Arumainayagam, Nimalan
Moore, C. M.
Ahmed, Hashim U.
Emberton, M.
[J]. WORLD JOURNAL OF UROLOGY, 2010, 28 (05) : 571 - 576
[3] Changes in in vivo optical properties and light distributions in normal canine prostate during photodynamic therapy
Chen, Q
Wilson, BC
Shetty, SD
Patterson, MS
Cerny, JC
Hetzel, FW
[J]. RADIATION RESEARCH, 1997, 147 (01) : 86 - 91
[4] Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer
Davidson, Sean R. H.
Weersink, Robert A.
Haider, Masoom A.
Gertner, Mark R.
Bogaards, Arjen
Giewercer, David
Scherz, Avigdor
Sherar, Michael D.
Elhilali, Mostafa
Chin, Joseph L.
Trachtenberg, John
Wilson, Brian C.
[J]. PHYSICS IN MEDICINE AND BIOLOGY, 2009, 54 (08) : 2293 - 2313
[5] Light dosimetry for multiple cylindrical diffusing sources for use in photodynamic therapy
Dickey, DJ
Partridge, K
Moore, RB
Tulip, J
[J]. PHYSICS IN MEDICINE AND BIOLOGY, 2004, 49 (14) : 3197 - 3208
[6] Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer
Du, K. L.
Mick, R.
Busch, T. M.
Zhu, T. C.
Finlay, J. C.
Yu, G.
Yodh, A. G.
Malkowicz, S. B.
Smith, D.
Whittington, R.
Stripp, D.
Hahn, S. M.
[J]. LASERS IN SURGERY AND MEDICINE, 2006, 38 (05) : 427 - 434
[7] Focal Treatment of Prostate Cancer with Vascular-Targeted Photodynamic Therapy
Eggener, Scott E.
Coleman, Jonathan A.
[J]. THESCIENTIFICWORLDJOURNAL, 2008, 8 : 963 - 973
[8] PHOTODOSIMETRY OF INTERSTITIAL LIGHT DELIVERY TO SOLID TUMORS
FENNING, MC
BROWN, DQ
CHAPMAN, JD
[J]. MEDICAL PHYSICS, 1994, 21 (07) : 1149 - 1156
[9] Prostate gland: MR imaging appearance after vascular targeted photodynamic therapy with palladium-bacteriopheophorbide
Haider, Masoom A.
Davidson, Sean R. H.
Kale, Ashwini V.
Weersink, Robert A.
Evans, Andrew J.
Toi, Ants
Gertner, Mark R.
Bogaards, Arjen
Wilson, Brian C.
Chin, Joseph L.
Elhilali, Mostafa
Trachtenberg, John
[J]. RADIOLOGY, 2007, 244 (01) : 196 - 204
[10] Realtime light dosimetry software tools for interstitial photodynamic therapy of the human prostate
Johansson, Ann
Axelsson, Johan
Andersson-Engels, Stefan
Swartling, Johannes
[J]. MEDICAL PHYSICS, 2007, 34 (11) : 4309 - 4321

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