Antioxidants as a Potential Target against Inflammation and Oxidative Stress in Attention-Deficit/Hyperactivity Disorder

被引：52

作者：

Alvarez-Arellano, Lourdes ^{[1
]}

Gonzalez-Garcia, Nadia ^{[2
]}

Salazar-Garcia, Marcela ^{[3
]}

Corona, Juan Carlos ^{[2
]}

机构：

[1] Hosp Infantil Mexico Dr Federico Gomez, CONACYT, Mexico City 06720, DF, Mexico

[2] Hosp Infantil Mexico Dr Federico Gomez, Lab Neurosci, Mexico City 06720, DF, Mexico

[3] Hosp Infantil Mexico Dr Federico Gomez, Lab Invest Biol Desarrollo & Teratogenesis Expt, Mexico City 06720, DF, Mexico

来源：

ANTIOXIDANTS | 2020年 / 9卷 / 02期

关键词：

antioxidants; ADHD; inflammation; oxidative stress; Nrf2; DEFICIT HYPERACTIVITY DISORDER; POLYUNSATURATED FATTY-ACIDS; N-ACETYLCYSTEINE; DOUBLE-BLIND; METHYLPHENIDATE TREATMENT; EXTRACELLULAR LEVELS; PREFRONTAL CORTEX; ANIMAL-MODEL; T-CELLS; CHILDREN;

D O I：

10.3390/antiox9020176

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psychostimulants and non-psychostimulants are the medications prescribed for the treatment of attention-deficit/hyperactivity disorder (ADHD). However, several adverse results have been linked with an increased risk of substance use and side effects. The pathophysiology of ADHD is not completely known, although it has been associated with an increase in inflammation and oxidative stress. This review presents an overview of findings following antioxidant treatment for ADHD and describes the potential amelioration of inflammation and oxidative stress using antioxidants that might have a future as multi-target adjuvant therapy in ADHD. The use of antioxidants against inflammation and oxidative conditions is an emerging field in the management of several neurodegenerative and neuropsychiatric disorders. Thus, antioxidants could be promising as an adjuvant ADHD therapy.

引用

页数：17

共 142 条

[1] Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation [J].

Abdel-Wahab, Wessam M. ;

Moussa, Farouzia, I .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2019, 13 :1155-1162

[2] Controlled trial of N-acetyleysteine for patients with probable Alzheimer's disease [J].

Adair, JC ;

Knoefel, JE ;

Morgan, N .

NEUROLOGY, 2001, 57 (08) :1515-1517

[3] Nrf2 signaling pathway: Pivotal roles in inflammation [J].

Ahmed, Syed Minhaj Uddin ;

Luo, Lin ;

Namani, Akhileshwar ;

Wang, Xiu Jun ;

Tang, Xiuwen .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2017, 1863 (02) :585-597

[4] Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats [J].

Aladaileh, Saleem H. ;

Hussein, Omnia E. ;

Abukhalil, Mohammad H. ;

Saghir, Sultan A. M. ;

Bin-Jumah, May ;

Alfwuaires, Manal A. ;

Germoush, Mousa O. ;

Almaiman, Amer A. ;

Mahmoud, Ayman M. .

ANTIOXIDANTS, 2019, 8 (10)

[5] DNA damage in rats after treatment with methylphenidate [J].

Andreazza, Ana Cristina ;

Frey, Benicio N. ;

Valvassori, Samira S. ;

Zanotto, Caroline ;

Gomes, Karin M. ;

Comim, Clarissa M. ;

Stertz, Laura ;

Ribeiro, Leticia C. ;

Quevedo, Joao ;

Kapczinski, Flavio ;

Berk, Michael ;

Goncalves, Carlos Alberto .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2007, 31 (06) :1282-1288

[6]

[Anonymous], 2019, CELLS BASEL, DOI DOI 10.3390/CELLS8101293

[7] Omega-3 Fatty Acids and Neurodegenerative Diseases: New Evidence in Clinical Trials [J].

Avallone, Rossella ;

Vitale, Giovanni ;

Bertolotti, Marco .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (17)

[8] Elevated Melatonin Levels in Children With Attention Deficit Hyperactivity Disorder: Relationship to Oxidative and Nitrosative Stress [J].

Avcil, Sibelnur ;

Uysal, Pinar ;

Yenisey, Cigdem ;

Abas, Burcin Irem .

JOURNAL OF ATTENTION DISORDERS, 2021, 25 (05) :693-703

[9] Alpha-2 Adrenergic Receptors and Attention-Deficit/Hyperactivity Disorder [J].

Bidwell, L. Cinnamon ;

Dew, Rachel E. ;

Kollins, Scott H. .

CURRENT PSYCHIATRY REPORTS, 2010, 12 (05) :366-373

[10] N-Acetylcysteine in the Treatment of Pediatric Tourette Syndrome: Randomized, Double-Blind, Placebo-Controlled Add-On Trial [J].

Bloch, Michael H. ;

Panza, Kaitlyn E. ;

Yaffa, Alisa ;

Alvarenga, Pedro G. ;

Jakubovski, Ewgeni ;

Mulqueen, Jilian M. ;

Landeros-Weisenberger, Angeli ;

Leckman, James F. .

JOURNAL OF CHILD AND ADOLESCENT PSYCHOPHARMACOLOGY, 2016, 26 (04) :327-334

← 1 2 3 4 5 6 7 8 9 10 →