S-15183a and b, new sphingosine kinase inhibitors, produced by a fungus

被引：33

作者：

Kono, K

Tanaka, M

Ono, Y

Hosoya, T

Ogita, T

Kohama, T

机构：

[1] Sankyo Co Ltd, Inst Res, Pharmacol & Mol Biol Res Labs, Tokyo 1408710, Japan

[2] Sankyo Co Ltd, Inst Res, Exploratory Chem Res Labs, Tokyo 1408710, Japan

[3] Sankyo Co Ltd, Inst Res, Lead Discovery Res Labs, Tokyo 1408710, Japan

[4] Sankyo Co Ltd, Inst Res, Drug Metab & Pharmacokinet Res Labs, Tokyo 1408710, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2001年 / 54卷 / 05期

关键词：

D O I：

10.7164/antibiotics.54.415

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In the course of our screening for inhibitors of sphingosine kinase, we found two active compounds in a culture broth of a fungus, Zopfiella inermis SANK 15183. The structures of the compounds, named S-15183a and b, were elucidated by a combination of spectroscopic analyses to be new azaphilone-type metabolites. S-15183a and b inhibited sphingosine kinase from rat liver with IC50 values of 2.5 and 1.6 muM, respectively. S-15183a also inhibited endogenous SPH kinase activity in intact platelets.

引用

页码：415 / 420

页数：6

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