Protective role of Methanol extract of Phyllanthus Polyphyllus against N-nitrosodiethylamine induced liver tumor in rat

被引：0

作者：

Maideen, Naina Mohamed Pakkir ^{[1
]}

Velayutham, Ravichandiran ^{[1
]}

Manavalan, Gobinath ^{[2
]}

机构：

[1] Vels Univ, Coll Pharm, Dept Pharmacol, Madras 600117, Tamil Nadu, India

[2] Ratnam Inst Pharm, Nellore 524346, Andhra Pradesh, India

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2010年 / 5卷 / 02期

关键词：

Phyllanthus polyphyllus; Liver tumor; N-nitrosodiethylamine; Glycoprotein; ACID; GLUTATHIONE; ENZYMES; CONSTITUENTS; HEPATOMA; ASSAY;

D O I：

10.3329/bjp.v5i2.6750

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The protective role of methanol extract of Phyllanthus polyphyllus was evaluated in N-nitrosodiethylamine-induced experimental liver tumor in male Wistar albino rats. Administration of extract (200 and 400 mg/kg) effectively suppressed liver tumor as revealed by decrease in elevated levels of Phase I enzymes like cytochrome P450, cytochrome b5, NADPH-cytochrome P450 reductase and glycoproteins like hexose, hexoseamine and sialic acid. The extract produced an increase in phase II enzymes like UDP-glucuronyl transferase and glutathione-S-transferase levels when compared to liver tumor bearing animals. This study suggests that methanol extract of P. polyphyllus may extend its protective role by modulating the levels of glycoproteins and phase I metabolizing enzymes and augmenting phase II metabolizing enzymes.

引用

页码：85 / 88

页数：4