Cancer-related accelerated ageing and biobehavioural modifiers: a framework for research and clinical care

被引：52

作者：

Carroll, Judith E. ^{[1
,2
,3
]}

Bower, Julienne E. ^{[1
,2
,3
,4
]}

Ganz, Patricia A. ^{[3
,5
,6
]}

机构：

[1] Univ Calif Los Angeles, Jane & Terry Semel Inst Neurosci & Human Behav, Norman Cousins Ctr Psychoneuroimmunol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA

[5] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Dept Hlth Policy & Management, Los Angeles, CA USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Hematol Oncol, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS CLINICAL ONCOLOGY | 2022年 / 19卷 / 03期

基金：

美国国家卫生研究院;

关键词：

COGNITIVE-BEHAVIORAL THERAPY; QUALITY-OF-LIFE; LEUKOCYTE TELOMERE LENGTH; ACUTE PSYCHOLOGICAL STRESS; EPIGENETIC CLOCK ANALYSIS; ARTERY RISK DEVELOPMENT; BREAST-CANCER; PHYSICAL-ACTIVITY; DNA-DAMAGE; LONG-TERM;

D O I：

10.1038/s41571-021-00580-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A growing body of evidence indicates that patients with cancer who receive cytotoxic treatments (such as chemotherapy or radiotherapy) have an increased risk of accelerated physical and cognitive ageing. Furthermore, accelerated biological ageing is a suspected driving force behind many of these observed effects. In this Review, we describe the mechanisms of biological ageing and how they apply to patients with cancer. We highlight the important role of specific behavioural factors, namely stress, sleep and lifestyle-related factors such as physical activity, weight management, diet and substance use, in the accelerated ageing of patients with cancer and cancer survivors. We also present a framework of how modifiable behaviours could operate to either increase the risk of accelerated ageing, provide protection, or promote resilience at both the biological level and in terms of patient-reported outcomes.

引用

页码：173 / 187

页数：15

共 293 条

[31] Childhood maltreatment and monocyte gene expression among women with breast cancer [J].