Uncovering a Tumor Suppressor for Triple-Negative Breast Cancers

被引：24

作者：

Albeck, John G. ^{[1
]}

Brugge, Joan S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CELL | 2011年 / 144卷 / 05期

关键词：

D O I：

10.1016/j.cell.2011.02.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

"Triple-negative" breast cancers are aggressive malignancies that respond poorly to treatments. Now Sun et al. (2011) find that the activity of the protein tyrosine phosphatase PTPN12 is lost in a large percentage of this breast cancer subtype, offering molecular drivers and possible therapeutic targets for this heterogeneous and intractable cancer.

引用

页码：638 / 640

页数：3

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