Age to survive: DNA damage and aging

被引：197

作者：

Schumacher, Bjorn ^{[1
]}

Garinis, George A. ^{[1
]}

Hoeijmakers, Jan H. J. ^{[1
]}

机构：

[1] Erasmus MC, MGC Dept Cell Biol & Genet, Ctr Biomed Genet, NL-3000 DR Rotterdam, Netherlands

来源：

TRENDS IN GENETICS | 2008年 / 24卷 / 02期

关键词：

D O I：

10.1016/j.tig.2007.11.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Aging represents the progressive functional decline and increased mortality risk common to nearly all metazoans. Recent findings experimentally link DNA damage and organismal aging: longevity-regulating genetic pathways respond to the accumulation of DNA damage and other stress conditions and conversely influence the rate of damage accumulation and its impact for cancer and aging. This novel insight has emerged from studies on human progeroid diseases and mouse models that have deficient DNA repair pathways. Here we discuss a unified concept of an evolutionarily conserved 'survival' response that shifts the organism's resources from growth to maintenance as an adaptation to stresses, such as starvation and DNA damage. This shift protects the organism from cancer and promotes healthy aging.

引用

页码：77 / 85

页数：9

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