Retinoic acid: A key player in immunity

被引：82
作者：
Pino-Lagos, Karina [1 ]
Guo, Yanxia [1 ]
Noelle, Randolph J. [1 ,2 ,3 ]
机构：
[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA
[2] Norris Cotton Canc Ctr, Lebanon, NH USA
[3] Kings Coll London, Dept Nephrol & Transplantat, London WC2R 2LS, England
来源：
BIOFACTORS | 2010年 / 36卷 / 06期
基金：
英国医学研究理事会;
关键词：
retinoic acid; vitamin A; inflammation; ACUTE PROMYELOCYTIC LEUKEMIA; REGULATORY T-CELLS; VITAMIN-A; DENDRITIC CELLS; X-RECEPTOR; SMALL-INTESTINE; MYELOID CELLS; TNF-ALPHA; EXPRESSION; DIFFERENTIATION;
D O I：
10.1002/biof.117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
For the past loo years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment. (C) 2010 International Union of Biochemistry and Molecular Biology, Inc. Volume 36, Number 6, November/December 2010, Pages 430-436. E-mail: rjn@dartmouth.edu
引用
收藏
页码：430 / 436
页数：7
相关论文
共 50 条
  • [41] Divergent functions for airway epithelial matrix metalloproteinase 7 and retinoic acid in experimental asthma
    Goswami, Sangeeta
    Angkasekwinai, Pornpimon
    Shan, Ming
    Greenlee, Kendra J.
    Barranco, Wade T.
    Polikepahad, Sumanth
    Seryshev, Alexander
    Song, Li-zhen
    Redding, David
    Singh, Bhupinder
    Sur, Sanjiv
    Woodruff, Prescott
    Dong, Chen
    Corry, David B.
    Kheradmand, Farrah
    NATURE IMMUNOLOGY, 2009, 10 (05) : 496 - 503
  • [42] Retinoic acid and TGF-β orchestrate organ-specific programs of tissue residency
    Obers, Andreas
    Poch, Tobias
    Rodrigues, Grace
    Christo, Susan N.
    Gandolfo, Luke C.
    Fonseca, Raissa
    Zaid, Ali
    Kuai, Joey En Yu
    Lai, Hongjin
    Zareie, Pirooz
    Yakou, Marina H.
    Dryburgh, Lachlan
    Burn, Thomas N.
    Dosser, James
    Buquicchio, Frank A.
    Lareau, Caleb A.
    Walsh, Calum
    Judd, Louise
    Theodorou, Maria Rafailia
    Gutbrod, Katharina
    Doermann, Peter
    Kingham, Jenny
    Stinear, Tim
    Kallies, Axel
    Schroeder, Jan
    Mueller, Scott N.
    Park, Simone L.
    Speed, Terence P.
    Satpathy, Ansuman T.
    Phan, Tri Giang
    Wilhelm, Christoph
    Zaph, Colby
    Evrard, Maximilien
    Mackay, Laura K.
    IMMUNITY, 2024, 57 (11) : 2615 - +
  • [43] Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8+ T Cell-Mediated Immunity in Colorectal Cancer
    Bhattacharya, Nupur
    Yuan, Robert
    Prestwood, Tyler R.
    Penny, Hweixian Leong
    DiMaio, Michael A.
    Reticker-Flynn, Nathan E.
    Krois, Charles R.
    Kenkel, Justin A.
    Pham, Tho D.
    Carmi, Yaron
    Tolentino, Lorna
    Choi, Okmi
    Hulett, Reyna
    Wang, Jinshan
    Winer, Daniel A.
    Napoli, Joseph L.
    Engleman, Edgar G.
    IMMUNITY, 2016, 45 (03) : 641 - 655
  • [44] Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers
    Yamada, Shigeru
    Kanda, Yasunari
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2019, 140 (04) : 337 - 344
  • [45] Retinoic acid decreases the severity of Salmonella enterica serovar Typhimurium mediated gastroenteritis in a mouse model
    Sinha, Ritam
    Howlader, Debaki Ranjan
    Mukherjee, Priyadarshini
    Rai, Sulabh
    Nag, Dhrubajyoti
    Koley, Hemanta
    IMMUNOBIOLOGY, 2016, 221 (07) : 839 - 844
  • [46] Potential for use of retinoic acid as an oral vaccine adjuvant
    Mwanza-Lisulo, Mpala
    Kelly, Paul
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2015, 370 (1671)
  • [47] Oncogenic and cell survival properties of the retinoic acid metabolizing enzyme, CYP26A1
    Osanai, M.
    Sawada, N.
    Lee, G-H
    ONCOGENE, 2010, 29 (08) : 1135 - 1144
  • [48] Retinoic acid has the potential to suppress endometriosis development
    Yamagata, Yoshiaki
    Takaki, Eiichi
    Shinagawa, Masahiro
    Okada, Maki
    Jozaki, Kosuke
    Lee, Lifa
    Sato, Shun
    Maekawa, Ryo
    Taketani, Toshiaki
    Asada, Hiromi
    Tamura, Hiroshi
    Nakai, Akira
    Sugino, Norihiro
    JOURNAL OF OVARIAN RESEARCH, 2015, 8
  • [49] Effect of Retinoic Acid in a Mouse Model of Allergic Rhinitis
    Son, Hye-Lim
    Park, Hyang-Rim
    Park, Yong-Jin
    Kim, Soo-Whan
    ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2015, 7 (06) : 590 - 598
  • [50] Patterning of retinoic acid signaling and cell proliferation in the hippocampus
    Goodman, Timothy
    Crandall, James E.
    Nanescu, Sonia E.
    Quadro, Loredana
    Shearer, Kirsty
    Ross, Alexander
    McCaffery, Peter
    HIPPOCAMPUS, 2012, 22 (11) : 2171 - 2183
12345