Retinoic acid: A key player in immunity

被引：80
作者：
Pino-Lagos, Karina [1 ]
Guo, Yanxia [1 ]
Noelle, Randolph J. [1 ,2 ,3 ]
机构：
[1] Dartmouth Med Sch, Dept Microbiol & Immunol, Lebanon, NH 03756 USA
[2] Norris Cotton Canc Ctr, Lebanon, NH USA
[3] Kings Coll London, Dept Nephrol & Transplantat, London WC2R 2LS, England
来源：
BIOFACTORS | 2010年 / 36卷 / 06期
基金：
英国医学研究理事会;
关键词：
retinoic acid; vitamin A; inflammation; ACUTE PROMYELOCYTIC LEUKEMIA; REGULATORY T-CELLS; VITAMIN-A; DENDRITIC CELLS; X-RECEPTOR; SMALL-INTESTINE; MYELOID CELLS; TNF-ALPHA; EXPRESSION; DIFFERENTIATION;
D O I：
10.1002/biof.117
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
For the past loo years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment. (C) 2010 International Union of Biochemistry and Molecular Biology, Inc. Volume 36, Number 6, November/December 2010, Pages 430-436. E-mail: rjn@dartmouth.edu
引用
收藏
页码：430 / 436
页数：7
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