Extramedullary Hematopoiesis Visualized on FDG-PET/CT in a Patient with Beta-Thalassemia

被引:1
作者
Dahlsgaard-Wallenius, Sara E. [1 ]
Juul-Jensen, Karen [2 ]
Nielsen, Anne Lerberg [1 ]
Hildebrandt, Malene Grubbe [1 ,3 ,4 ]
机构
[1] Odense Univ Hosp, Dept Nucl Med, Odense, Denmark
[2] Odense Univ Hosp, Dept Hematol, Odense, Denmark
[3] Univ Southern Denmark, Dept Clin Res, Odense, Denmark
[4] Odense Univ Hosp, Ctr Innovat Med Technol CIMT, Odense, Denmark
关键词
Thalassemia; Extramedullary Hematopoiesis; Fluoro-2-deoxyglucose; Positron Emission Tomography; computer Tomography;
D O I
10.1007/s13139-022-00773-3
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Beta-thalassemia is an inherited blood disorder caused by reduced or absent synthesis of the beta chains of hemoglobin, resulting in decreased hemoglobin production. Symptoms depend on the type of beta-thalassemia ranging from no symptoms to severe illness. Ineffective erythropoiesis leads to a sequence of events responsible for bone marrow expansion, anemia, hemolysis, splenomegaly, increased iron absorption, and sometimes extramedullary hematopoiesis (EMH). We report an interesting case with EMH visualized on FDG-PET/CT and where FDG-PET/CT has also found the focus of a severe infection in a patient with beta-thalassemia.
引用
收藏
页码:328 / 330
页数:3
相关论文
共 11 条
[1]   Presacral and intrathoracic extramedullary hematopoiesis: a case report [J].
Balci, Yasemin Isik ;
Kaya, Vildan ;
Atesci, Mustafa Serdar .
CLINICAL IMAGING, 2012, 36 (04) :406-408
[2]  
Chehal Aref, 2003, Spine (Phila Pa 1976), V28, pE245, DOI 10.1097/00007632-200307010-00024
[3]   Effect of transfusional iron intake on response to chelation therapy in β-thalassemia major [J].
Cohen, Alan R. ;
Glimm, Ekkehard ;
Porter, John B. .
BLOOD, 2008, 111 (02) :583-587
[4]   Clinical and hematologic aspects of hemoglobin E β-thalassemia [J].
Fucharoen, S ;
Winichagoon, P .
CURRENT OPINION IN HEMATOLOGY, 2000, 7 (02) :106-112
[5]   Mass-like extramedullary hematopoiesis: imaging features [J].
Ginzel, Andrew W. ;
Kransdorf, Mark J. ;
Peterson, Jeffrey J. ;
Garner, Hillary W. ;
Murphey, Mark D. .
SKELETAL RADIOLOGY, 2012, 41 (08) :911-916
[6]   Presacral extramedullary hematopoiesis: report of a case and review of the literature [J].
Gupta, Pramod ;
Eshaghi, Nahid ;
Ghole, Vidisha ;
Ketkar, Manoj ;
Garcia-Morales, Francisco .
CLINICAL IMAGING, 2008, 32 (06) :487-489
[7]  
Lotfollahzadeh S., 2021, Splenic abscess
[8]   Effect of hydroxyurea on extramedullary haematopoiesis in thalassaemia intermedia: case reports and literature review [J].
Meo, A. ;
Cassinerio, E. ;
Castelli, R. ;
Bignamini, D. ;
Perego, L. ;
Cappellini, M. D. .
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2008, 30 (05) :425-431
[9]   PET CT imaging in extramedullary hematopoiesis and lung cancer surprise in a case with thalassemia intermedia [J].
Paydas, Semra ;
Sargin, Ozogul ;
Gonlusen, Gulfiliz .
TURKISH JOURNAL OF HEMATOLOGY, 2011, 28 (01) :60-62
[10]   How I treat thalassemia [J].
Rachmilewitz, Eliezer A. ;
Giardina, Patricia J. .
BLOOD, 2011, 118 (13) :3479-3488