The Distribution of Obesity Phenotypes in HIV-Infected African Population

被引：9

作者：

Nguyen, Kim Anh ^{[1
,2
]}

Peer, Nasheeta ^{[1
,2
]}

de Villiers, Anniza ^{[1
]}

Mukasa, Barbara ^{[3
]}

Matsha, Tandi E. ^{[4
]}

Mills, Edward J. ^{[5
]}

Kengne, Andre Pascal ^{[1
,2
]}

机构：

[1] South African Med Res Council, Noncommunicable Dis Res Unit, ZA-7505 Cape Town, South Africa

[2] Univ Cape Town, Dept Med, ZA-7935 Cape Town, South Africa

[3] United Nations Populat Fund UNFPA, Mildmay Uganda POB 24985, Lweza, Uganda

[4] Cape Peninsula Univ Technol, Dept Biomed Sci, Fac Hlth & Wellness Sci, ZA-7535 Cape Town, South Africa

[5] Global Evaluat Sci, Vancouver, BC V6H 3X4, Canada

来源：

NUTRIENTS | 2016年 / 8卷 / 06期

关键词：

obesity phenotype; metabolic abnormalities; HIV infection; METABOLICALLY HEALTHY OBESITY; NORMAL-WEIGHT; PREVALENCE; MORTALITY; DETERMINANTS; DISEASE; DEATH; RISK;

D O I：

10.3390/nu8060299

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The distribution of body size phenotypes in people with human immunodeficiency virus (HIV) infection has yet to be characterized. We assessed the distribution of body size phenotypes overall, and according to antiretroviral therapy (ART), diagnosed duration of the infection and CD4 count in a sample of HIV infected people recruited across primary care facilities in the Western Cape Province, South Africa. Adults aged >= 18 years were consecutively recruited using random sampling procedures, and their cardio-metabolic profile were assessed during March 2014 and February 2015. They were classified across body mass index (BMI) categories as normal-weight (BMI < 25 kg/m(2)), overweight (25 <= BMI < 30 kg/m(2)), and obese (BMI >= 30 kg/m(2)), and further classified according to their metabolic status as "metabolically healthy" vs. "metabolically abnormal" if they had less than two vs. two or more of the following abnormalities: high blood glucose, raised blood pressure, raised triglycerides, and low HDL-cholesterol. Their cross-classification gave the following six phenotypes: normal-weight metabolically healthy (NWMH), normal-weight metabolically abnormal (NWMA), overweight metabolically healthy (OvMH), overweight metabolically abnormal (OvMA), obese metabolically healthy (OMH), and obese metabolically abnormal (OMA). Among the 748 participants included (median age 38 years (25th-75th percentiles: 32-44)), 79% were women. The median diagnosed duration of HIV was five years; the median CD4 count was 392 cells/mm(3) and most participants were on ART. The overall distribution of body size phenotypes was the following: 31.7% (NWMH), 11.7% (NWMA), 13.4% (OvMH), 9.5% (OvMA), 18.6% (OMH), and 15.1% (OMA). The distribution of metabolic phenotypes across BMI levels did not differ significantly in men vs. women (p = 0.062), in participants below vs. those at or above median diagnosed duration of HIV infection (p = 0.897), in participants below vs. those at or above median CD4 count (p = 0.447), and by ART regimens (p = 0.205). In this relatively young sample of HIV-infected individuals, metabolically abnormal phenotypes are frequent across BMI categories. This highlights the importance of general measures targeting an overall improvement in cardiometabolic risk profile across the spectrum of BMI distribution in all adults with HIV.

引用

页数：17

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