Label-free Biosensing Based on Single Gold Nanostars as Plasmonic Transducers

被引:287
作者
Dondapati, Srujan K. [1 ,2 ]
Sau, Tapan K. [1 ,2 ]
Hrelescu, Calin [1 ,2 ]
Klar, Thomas A. [3 ,4 ]
Stefani, Fernando D. [1 ,2 ,3 ,4 ]
Feldmann, Jochen [1 ,2 ]
机构
[1] Univ Munich, Dept Phys, Photon & Optoelect Grp, D-80799 Munich, Germany
[2] Univ Munich, Ctr Nanosci CeNS, D-80799 Munich, Germany
[3] Tech Univ Ilmenau, Inst Phys, D-98684 Ilmenau, Germany
[4] Tech Univ Ilmenau, Inst Micro & Nanotechnol, D-98684 Ilmenau, Germany
关键词
localized surface plasmon resonance; nanoparticle; nanostar; biosensing; streptavidin; biotin; SILVER NANOPARTICLES; OPTICAL-PROPERTIES; REAL-TIME; RESONANCE; SHAPE; SIZE; SENSITIVITY; SENSOR;
D O I
10.1021/nn100760f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Gold nanostars provide high sensitivity for single nanoparticle label free biosensing The nanostars present multiple plasmon resonances of which the lower energy ones, corresponding to the nanostar tips and core-tip interactions are the most sensitive to environmental changes streptavidin molecules are detected upon binding to individual biotin modified gold nanostars by spectral shifts in the plasmon resonances Concentrations at low as 0 1 nM produce a shift of the tip related plasmon resonances of about 2 3 nm (5 3 meV)
引用
收藏
页码:6318 / 6322
页数:5
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