Cancer following hip and knee arthroplasty: record linkage study

被引：30

作者：

Goldacre, MJ ^{[1
]}

Wotton, CJ ^{[1
]}

Seagroatt, V ^{[1
]}

Yeates, D ^{[1
]}

机构：

[1] Univ Oxford, Dept Publ Hlth, Unit Hlth Care Epidemiol, Oxford OX3 7LF, England

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 07期

关键词：

arthroplasty; lymphoma; leukaemia; disease associations; record linkage;

D O I：

10.1038/sj.bjc.6602511

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Concerns have been raised that degradation of implants used in hip and knee arthroplasty may lead to an increased risk of some cancers, particularly those of the haematopoietic, lymphatic and urinary systems. We used linked statistical records of hospital admissions and deaths to compare cancer rates in cohorts of people who had undergone hip or knee arthroplasty with a comparison cohort. We did not find an elevated risk for cancer, overall, in either the hip or knee cohort or in both combined ( rate ratio for both combined 0.99; 95% confidence intervals 0.95 - 1.02), or for haematopoietic, lymphatic or urinary system cancers. There was also no elevation in risk of cancer more than 10 years after arthroplasty. Our findings add to the evidence that arthroplasty is safe in respect of cancer risk.

引用

页码：1298 / 1301

页数：4

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