Left atrial function index in embolic stroke of undetermined source: A case-control study

被引:2
作者
Tajmirriahi, Marzieh [1 ]
Salari, Parisa [2 ]
Saadatnia, Mohammad [3 ]
机构
[1] Isfahan Univ Med Sci, Hypertens Res Ctr, Isfahan Cardiovasc Res Inst, Esfahan, Iran
[2] Isfahan Univ Med Sci, Dept Cardiol, Esfahan, Iran
[3] Isfahan Univ Med Sci, Isfahan Neurosci Res Ctr, Esfahan, Iran
关键词
embolic stroke undetermined source; Left atrial function index; left atrial volume index; left atrial diameter index; FIBRILLATION; PREVENTION; PREDICTION; VOLUME; STRAIN;
D O I
10.54029/2022cnz
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background & Objectives: Previous studies showed left atrial volume index (LAVi) is a precise surrogate of atrial cardiopathy and associated with new-onset atrial fibrillation and embolic stroke undetermined source (ESUS). Recent data suggest that the left atrial functional index (LAFi) is associated with the risk of developing AF recurrence. However, there was no study to show LAFi in ESUS. We aim to compare the performance of different surrogates of atrial cardiopathy (LAVi and LAFi) in a cohort of ESUS patients and healthy adults. Methods: Between Dec 2018 to Feb 2020, consecutive patients diagnosed with ESUS and normal healthy controls (>18 years) were included. Left atrial diameter (LAD), left atrial diameter index (LADi), LAVi and LAFi were measured by transthoracic echocardiogram under American Society of Echocardiography guidelines. Results: A total of 125 patients (43 controls and 82 ESUS patients) were compared. Significant differences of LADi, LAVi, and LAFi were detected between ESUS and control (p=0.04, p=0.002, and p=0.001, respectively). On adjustment for age, sex, hypertension, and diabetes mellitus, LADi and LAVi the association with ESUS and LAFi (aOR decrease, 0.928; 95% CI 0.882-0.976; p = 0.004) remained significant and LAD, LADi, and LAVi were not associated with ESUS in this analysis. Conclusions: LAFi may be a more comprehensive predictor of atrial cardiopathy as compared to LADi and LAVi in risk stratification of ESUS or cryptogenic stroke.
引用
收藏
页码:275 / 279
页数:5
相关论文
共 22 条
  • [1] Left atrial volume in the prediction of first ischemic stroke in an elderly cohort without atrial fibrillation
    Barnes, ME
    Miyasaka, Y
    Seward, JB
    Gersh, BJ
    Rosales, AG
    Bailey, KR
    Petty, GW
    Wiebers, DO
    Tsang, TSM
    [J]. MAYO CLINIC PROCEEDINGS, 2004, 79 (08) : 1008 - 1014
  • [2] Impairment of left atrial function and cryptogenic stroke: Potential insights in the pathophysiology of stroke in the young
    Bhat, Aditya
    Khanna, Shaun
    Chen, Henry H.
    Lee, Lina
    Gan, Gary C. H.
    Negishi, Kazuaki
    MacIntyre, C. Raina
    Nunes, Maria Carmo P.
    Tan, Timothy C.
    [J]. IJC HEART & VASCULATURE, 2020, 26
  • [3] Left ventricular outflow tract velocity-time integral: A proper measurement technique is mandatory
    Blanco, Pablo
    [J]. VASCULAR MEDICINE, 2020, 25 (03) : 283 - 284
  • [4] Left atrial volumes: two-dimensional, three-dimensional, cardiac magnetic resonance and computed tomography measurements
    Boyd, Anita C.
    Thomas, Liza
    [J]. CURRENT OPINION IN CARDIOLOGY, 2014, 29 (05) : 408 - 416
  • [5] Temporal Relationship Between Subclinical Atrial Fibrillation and Embolic Events
    Brambatti, Michela
    Connolly, Stuart J.
    Gold, Michael R.
    Morillo, Carlos A.
    Capucci, Alessandro
    Muto, Carmine
    Lau, Chu P.
    Van Gelder, Isabelle C.
    Hohnloser, Stefan H.
    Carlson, Mark
    Fain, Eric
    Nakamya, Juliet
    Mairesse, Georges H.
    Halytska, Marta
    Deng, Wei Q.
    Israel, Carsten W.
    Healey, Jeff S.
    [J]. CIRCULATION, 2014, 129 (21) : 2094 - 2099
  • [6] Dabigatran for Prevention of Stroke after Embolic Stroke of Undetermined Source
    Diener, H. -C.
    Sacco, R. L.
    Easton, J. D.
    Granger, C. B.
    Bernstein, R. A.
    Uchiyama, S.
    Kreuzer, J.
    Cronin, L.
    Cotton, D.
    Grauer, C.
    Brueckmann, M.
    Chernyatina, M.
    Donnan, G.
    Ferro, J. M.
    Grand, M.
    Kallmuenzer, B.
    Krupinski, J.
    Lee, B. -C.
    Lemmens, R.
    Masjuan, J.
    Odinak, M.
    Saver, J. L.
    Schellinger, P. D.
    Toni, D.
    Toyoda, K.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (20) : 1906 - 1917
  • [7] Left Atrial Mechanical Function and Incident Ischemic Cerebrovascular Events Independent of AF Insights From the MESA Study
    Habibi, Mohammadali
    Zareian, Mytra
    Venkatesh, Bharath Ambale
    Samiei, Sanaz
    Imai, Masamichi
    Wu, Colin
    Launer, Lenore J.
    Shea, Steven
    Gottesman, Rebecca F.
    Heckbert, Susan R.
    Bluemke, David A.
    Lima, Joao A. C.
    [J]. JACC-CARDIOVASCULAR IMAGING, 2019, 12 (12) : 2417 - 2427
  • [8] Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source
    Hart, R. G.
    Sharma, M.
    Mundl, H.
    Kasner, S. E.
    Bangdiwala, S. I.
    Berkowitz, S. D.
    Swaminathan, B.
    Lavados, P.
    Wang, Y.
    Wang, Y.
    Davalos, A.
    Shamalov, N.
    Mikulik, R.
    Cunha, L.
    Lindgren, A.
    Arauz, A.
    Lang, W.
    Czlonkowska, A.
    Eckstein, J.
    Gagliardi, R. J.
    Amarenco, P.
    Ameriso, S. F.
    Tatlisumak, T.
    Veltkamp, R.
    Hankey, G. J.
    Toni, D.
    Bereczki, D.
    Uchiyama, S.
    Ntaios, G.
    Yoon, B. -W.
    Brouns, R.
    Endres, M.
    Muir, K. W.
    Bornstein, N.
    Ozturk, S.
    O'Donnell, M. J.
    Basson, M. M. De Vries
    Pare, G.
    Pater, C.
    Kirsch, B.
    Sheridan, P.
    Peters, G.
    Weitz, J. I.
    Peacock, W. F.
    Shoamanesh, A.
    Benavente, O. R.
    Joyner, C.
    Themeles, E.
    Connolly, S. J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (23) : 2191 - 2201
  • [9] Predictors of Recurrent Ischemic Stroke in Patients with Embolic Strokes of Undetermined Source and Effects of Rivaroxaban Versus Aspirin According to Risk Status: The NAVIGATE ESUS Trial
    Hart, Robert G.
    Veltkamp, Roland C.
    Sheridan, Patrick
    Sharma, Mukul
    Kasner, Scott E.
    Bangdiwala, Shrikant, I
    Ntaios, George
    Shoamanesh, Ashkan
    Ameriso, Sebastian F.
    Toni, Danilo
    Czlonkowska, Anna
    Lindgren, Arne
    Hankey, Graeme J.
    Perera, Kanjana S.
    Shuaib, Ashfaq
    Coutts, Shelagh B.
    Gagliardi, Rubens J.
    Berkowitz, Scott D.
    Mundl, Hardi
    Peters, Gary
    Connolly, Stuart J.
    [J]. JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 2019, 28 (08) : 2273 - 2279
  • [10] Embolic Stroke of Undetermined Source A Systematic Review and Clinical Update
    Hart, Robert G.
    Catanese, Luciana
    Perera, Kanjana S.
    Ntaios, George
    Connolly, Stuart J.
    [J]. STROKE, 2017, 48 (04) : 867 - 872