Plaque and tangle imaging and cognition in normal aging and Alzheimer's disease

被引：66

作者：

Braskie, Meredith N. ^{[2
,8
]}

Klunder, Andrea D. ^{[1
]}

Hayashi, Kiralee M. ^{[1
]}

Protas, Hillary ^{[3
,7
]}

Kepe, Vladimir ^{[3
]}

Miller, Karen J. ^{[4
]}

Huang, S. -C. ^{[3
]}

Barrio, Jorge R. ^{[3
]}

Ercoli, Linda M. ^{[4
]}

Siddarth, Prabha ^{[4
]}

Satyamurthy, Nagichettiar ^{[3
]}

Liu, Jie ^{[3
]}

Toga, Arthur W. ^{[1
]}

Bookheimer, Susan Y. ^{[2
,4
,6
]}

Small, Gary W. ^{[4
,5
]}

Thompson, Paul M. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Lab Neuro Imaging, Dept Neurol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Ahmanson Lovelace Brain Mapping Ctr, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Los Angeles, CA 90095 USA

[5] Univ Calif Los Angeles, Ctr Aging, Los Angeles, CA 90095 USA

[6] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychol, Los Angeles, CA 90095 USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biomath, Los Angeles, CA 90095 USA

[8] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

来源：

NEUROBIOLOGY OF AGING | 2010年 / 31卷 / 10期

基金：

美国国家卫生研究院;

关键词：

Amyloid; Cerebral cortex; Cognitive aging; Memory; PET; CORTICAL THICKNESS; CEREBRAL-CORTEX; A-BETA; BRAIN; POPULATION; IMPAIRMENT; DECLINE; TAU; PET; AGE;

D O I：

10.1016/j.neurobiolaging.2008.09.012

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Amyloid plaques and tau neurofibrillary tangles, the pathological hallmarks of Alzheimer's disease (AD), begin accumulating in the healthy human brain decades before clinical dementia symptoms can be detected. There is great interest in how this pathology spreads in the living brain and its association with cognitive deterioration. Using MRI-derived cortical surface models and four-dimensional animation techniques, we related cognitive ability to positron emission tomography (PET) signal from 2-(1-{6-[(2-[F-18]fluoroethyl)(methyl)amino]-2-naphthyl}ethylidene)malononitrile ([F-18]FDDNP), a molecular imaging probe for plaques and tangles. We examined this relationship at each cortical surface point in 23 older adults (10 cognitively intact, 6 with amnestic mild cognitive impairment, 7 with AD). [F-18]FDDNP-PET signal was highly correlated with cognitive performance, even in cognitively intact subjects. Animations of [18F]FDDNP signal growth with decreased cognition across all subjects (http://www.loni.ucla.edu/similar to thompson/FDDNP/video.html) mirrored the classic Braak and Braak trajectory in lateral temporal, parietal, and frontal cortices. Regions in which cognitive performance was significantly correlated with [F-18]FDDNP signal include those that deteriorate earliest in AD, suggesting the potential utility of [F-18]FDDNP for early diagnosis. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：1669 / 1678

页数：10

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