When the caps fall off: Responses to telomere uncapping in yeast

被引：15
作者：
Wellinger, Raymund J. [1 ]
机构：
[1] Univ Sherbrooke, Fac Med, Dept Microbiol & Infect Dis, Sherbrooke, PQ J1H 5N4, Canada
来源：
FEBS LETTERS | 2010年 / 584卷 / 17期
基金：
加拿大健康研究院;
关键词：
Telomere; Chromosome capping; DNA repair; DNA damage response; Cell cycle arrest; DNA-DAMAGE RESPONSE; SINGLE-STRANDED-DNA; SACCHAROMYCES-CEREVISIAE; UNPROTECTED TELOMERES; BUDDING YEAST; CHECKPOINT; END; REPLICATION; PROTEINS; BREAKS;
D O I：
10.1016/j.febslet.2010.06.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomeres protect the ends of linear chromosomes from activities that cause sequence losses or challenge chromosome integrity. Furthermore, these ends must be hidden from detection by the DNA damage recognition and response pathways. In particular, they must not fuse with each other. These fundamental and very first functions attributed to telomeres are also summarized with the term 'chromosome capping'. However, telomeres can become uncapped and the foremost cellular responses to such events aim to restore genome stability in the most conservative fashion possible. I will provide an outline of cellular responses to uncapping in budding yeast and briefly discuss the reverse, namely avoidance mechanisms that prevent telomere formation at inappropriate places. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码：3734 / 3740
页数：7
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