Synthesis and characterization of ultra-small superparamagnetic iron oxide nanoparticles thinly coated with silica

被引：117

作者：

Bumb, A. ^{[1
,2
]}

Brechbiel, M. W. ^{[2
]}

Choyke, P. L. ^{[3
]}

Fugger, L. ^{[4
]}

Eggeman, A. ^{[5
]}

Prabhakaran, D. ^{[6
]}

Hutchinson, J. ^{[6
]}

Dobson, P. J. ^{[1
]}

机构：

[1] Univ Oxford, Kidlington OX5 1PF, Oxon, England

[2] NCI, Radioimmune & Inorgan Chem Sect, Radiat Oncol Branch, NIH, Bethesda, MD 20892 USA

[3] NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA

[4] Univ Oxford, John Radcliffe Hosp, Weatherall Inst Mol Med, RC Human Immunol Unit, Oxford OX3 9DS, England

[5] Univ Oxford, Dept Mat, Oxford OX1 3PH, England

[6] Univ Oxford, Dept Phys, Oxford OX1 3PH, England

来源：

NANOTECHNOLOGY | 2008年 / 19卷 / 33期

关键词：

D O I：

10.1088/0957-4484/19/33/335601

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Ultra-small superparamagnetic iron oxide nanoparticles were synthesized by co-precipitation of iron chloride salts with ammonia and then encapsulated with thin (similar to 2 nm) layers of silica. The particles have been characterized for size, diffraction pattern, surface charge, and magnetic properties. This rapid and economical synthesis has a number of industrial applications; however, the silica-coated particles have been optimized for use in medical applications such as magnetic resonance contrast agents and biosensors, and in DNA capturing, bioseparation and enzyme immobilization.

引用

页数：6

共 38 条

[1] Ordered layers of monodispersive colloids [J].

Bardosova, M ;

Tredgold, RH .

JOURNAL OF MATERIALS CHEMISTRY, 2002, 12 (10) :2835-2842

[2] SYNTHESIS OF VERY FINE MAGHEMITE PARTICLES [J].

BEE, A ;

MASSART, R ;

NEVEU, S .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 1995, 149 (1-2) :6-9

[3]

CHAN DCF, 1993, J MAGN MAGN MATER, V122, P374, DOI 10.1016/0304-8853(93)91113-L

[4]

Cushing B. L., 2008, NANOTECHNOLOGY, V19, P1

[5] Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications [J].

Gupta, AK ;

Gupta, M .

BIOMATERIALS, 2005, 26 (18) :3995-4021

[6] NOVEL MAGNETIC DISPERSIONS USING SILICA STABILIZED PARTICLES [J].

HOMOLA, AM ;

LORENZ, MR ;

MASTRANGELO, CJ ;

TILBURY, TL .

IEEE TRANSACTIONS ON MAGNETICS, 1986, 22 (05) :716-719

[7] INTERFACIAL ELECTRON-TRANSFER IN COLLOIDAL SPINEL IRON-OXIDE - CONVERSION OF FE3O4-GAMMA-FE2O3 IN AQUEOUS-MEDIUM [J].

JOLIVET, JP ;

TRONC, E .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1988, 125 (02) :688-701

[8] Starch-coated superparamagnetic nanoparticles as MR contrast agents [J].

Kim, DK ;

Mikhaylova, M ;

Wang, FH ;

Kehr, J ;

Bjelke, B ;

Zhang, Y ;

Tsakalakos, T ;

Muhammed, M .

CHEMISTRY OF MATERIALS, 2003, 15 (23) :4343-4351

[9] Synthesis and characterization of surfactant-coated superparamagnetic monodispersed iron oxide nanoparticles [J].

Kim, DK ;

Zhang, Y ;

Voit, W ;

Rao, KV ;

Muhammed, M .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) :30-36

[10] Molecular packing of lysozyme, fibrinogen, and bovine serum albumin on hydrophilic and hydrophobic surfaces studied by infrared-visible sum frequency generation and fluorescence microscopy [J].

Kim, J ;

Somorjai, GA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2003, 125 (10) :3150-3158

← 1 2 3 4 →