Synthesis and antihypertensive activity of new 1,4-dihydropyridines

被引：0

作者：

Hadizadeh, F ^{[1
]}

Fatehi-Hassanabad, Z

Bamshad, M

Poorsoghat, H

Fatehi-Hassanabad, M

机构：

[1] Mashhad Univ Med Sci, Dept Med Chem, Fac Pharm, Mashhad, Iran

[2] Mashhad Univ Med Sci, Dept Physiol & Pharmacol, Fac Med, Mashhad, Iran

[3] Mashhad Univ Med Sci, Pharmaceut Sci Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Biotechnol Res Ctr, Mashhad, Iran

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2005年 / 44卷 / 11期

关键词：

antihypertensive activity; 1,4-dihydropyridines; imidazole; desoxycorticosterone acetate;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 1,4-dihydropyridines bearing dimethylamino 2a-f or 1H-imidazol-1-yl 3a-f side chain in the 2 position have been synthesized from unsubstituted ones 1a-f and tested for antihypertensive activity in desoxycorticosterone acetate (DOCA)-induced hypertensive rats. All the compounds have been found to be less active than nifedipine.

引用

页码：2343 / 2347

页数：5

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