The Wnt/β-catenin pathway as a therapeutic target in human hepatocellular carcinoma

被引：94

作者：

Dahmani, Rajae ^{[1
]}

Just, Pierre-Alexandre ^{[1
]}

Perret, Christine ^{[1
]}

机构：

[1] Univ Paris 05, INSERM, U1016, Inst Cochin,CNRS,UMR 8104, F-75014 Paris, France

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2011年 / 35卷 / 11期

关键词：

SMALL-MOLECULE ANTAGONISTS; BETA-CATENIN; IN-VIVO; GROWTH; CELLS; GENE; MUTATIONS; MOUSE; CANCER; LIVER;

D O I：

10.1016/j.clinre.2011.05.010

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. However, targeted therapies are still at their beginning for the treatment of this poor-prognosis tumor. Among the signaling cascades deregulated in HCC, the Wnt/beta-catenin signaling pathway plays a key role in hepatic oncogenesis. Although it has been shown, using HCC cell lines, that inhibition of the beta-catenin signaling has anti-tumoral effect, no molecules targeting the Wnt pathway are currently tested in clinical trials for the treatment of HCC. Here we review our current knowledge about the role of the Wnt/beta-catenin pathway in hepatocellular carcinoma pathogenesis and the benefits and limits of targeting this pathway in HCC. (C) 2011 Elsevier Masson SAS. All rights reserved.

引用

页码：709 / 713

页数：5

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