Iodine catalyzed one-pot synthesis of flavanone and tetrahydropyrimidine derivatives via Mannich type reaction

被引：57

作者：

Kavala, Veerababurao ^{[1
]}

Lin, Chunchi ^{[1
]}

Kuo, Chun-Wei ^{[1
]}

Fang, Hulin ^{[1
]}

Yao, Ching-Fa ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, Taipei 116, Taiwan

来源：

TETRAHEDRON | 2012年 / 68卷 / 04期

关键词：

Mannich reaction; Flavanones; Tetrahydropyrimidine; Iodine; BETA-AMINO KETONES; SURFACTANT-COMBINED CATALYST; 3-COMPONENT SYNTHESIS; MICHAEL ADDITION; STEREOSELECTIVE-SYNTHESIS; ALPHA; BETA-UNSATURATED KETONES; HETEROCYCLIC-COMPOUNDS; AROMATASE INHIBITORS; EFFICIENT SYNTHESIS; N-SULFONYLIMINES;

D O I：

10.1016/j.tet.2011.11.022

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of functionalized flavanone derivatives and tetrahydropyrimidine derivatives were achieved under remarkably mild conditions. The combination of good to excellent yields, a simple work-up, and the high compatibility of functional groups makes this an attractive synthetic approach to access flavanone and tetrahydropyrimidine derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1321 / 1329

页数：9

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