Total synthesis of cytotoxic macrolide amphidinolide B1 and the proposed structure of amphidinolide B2

被引：38

作者：

Lu, Liang ^{[1
]}

Zhang, Wei ^{[1
]}

Carter, Rich G. ^{[1
]}

机构：

[1] Oregon State Univ, Dept Chem, Corvallis, OR 97331 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 23期

关键词：

D O I：

10.1021/ja803012n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first enantioselective total syntheses of cytotoxic macrolide amphidinolide B, and the proposed structure for amphidinolide B-2 have been accomplished. Key features of the syntheses include a diastereoselective aldol condensation, a spontaneous Wadsworth-Emmons `macrocyclization and a directed epoxidation/elimination sequence.

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页码：7253 / +

页数：4

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