Modulation of α-tropomyosin expression by α-tocopherol in rat vascular smooth muscle cells

被引：66

作者：

Aratri, E ^{[1
]}

Spycher, SE ^{[1
]}

Breyer, I ^{[1
]}

Azzi, A ^{[1
]}

机构：

[1] Univ Bern, Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland

来源：

FEBS LETTERS | 1999年 / 447卷 / 01期

关键词：

alpha-tropomyosin; alpha-tocopherol; beta-tocopherol; vitamin E; differential display; smooth muscle cell;

D O I：

10.1016/S0014-5793(99)00277-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of alpha-tocopherol (vitamin E) on gene expression in rat vascular smooth muscle cells mas studied by the differential display technique. One gene out of about 1000 genes analyzed, identified as alpha-tropomyosin, showed an increased transcription level caused by cr-tocopherol treatment. Northern and Western blot analysis revealed a time-dependent transient up-regulation of the amount of mRNA (peak between 2 and 3 h) and protein (peak at 5 h) in alpha-tocopherol-treated cells. No effect mas observed in cells treated with beta-tocopherol. (C) 1999 Federation of European Biochemical Societies.

引用

页码：91 / 94

页数：4

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