Modulation of α-tropomyosin expression by α-tocopherol in rat vascular smooth muscle cells

被引：66
|
作者：
Aratri, E [1 ]
Spycher, SE [1 ]
Breyer, I [1 ]
Azzi, A [1 ]
机构：
[1] Univ Bern, Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland
来源：
FEBS LETTERS | 1999年 / 447卷 / 01期
关键词：
alpha-tropomyosin; alpha-tocopherol; beta-tocopherol; vitamin E; differential display; smooth muscle cell;
D O I：
10.1016/S0014-5793(99)00277-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of alpha-tocopherol (vitamin E) on gene expression in rat vascular smooth muscle cells mas studied by the differential display technique. One gene out of about 1000 genes analyzed, identified as alpha-tropomyosin, showed an increased transcription level caused by cr-tocopherol treatment. Northern and Western blot analysis revealed a time-dependent transient up-regulation of the amount of mRNA (peak between 2 and 3 h) and protein (peak at 5 h) in alpha-tocopherol-treated cells. No effect mas observed in cells treated with beta-tocopherol. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码：91 / 94
页数：4
相关论文
共 50 条
  • [1] The role for tropomyosin in vascular smooth muscle cells
    Kumagai, H
    Yoshiyama, S
    Li, S
    Xu, D
    Kohama, K
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004, 94 : 100P - 100P
  • [2] Expression and function of PPARγ in rat and human vascular smooth muscle cells
    Law, RE
    Goetze, S
    Xi, XP
    Jackson, S
    Kawano, Y
    Demer, L
    Fishbein, MC
    Meehan, WP
    Hsueh, WA
    CIRCULATION, 2000, 101 (11) : 1311 - 1318
  • [3] Protein expression changed by nicotine in rat vascular smooth muscle cells
    Wang, Z.
    Wu, W.
    Fang, X.
    Wang, Y.
    Xiao, C.
    Zhao, R.
    Wang, L.
    Qiao, Z.
    JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY, 2007, 63 (02) : 161 - 169
  • [4] Coordinate expression of alpha-tropomyosin and caldesmon isoforms in association with phenotypic modulation of smooth muscle cells
    Kashiwada, K
    Nishida, W
    Hayashi, K
    Ozawa, K
    Yamanaka, Y
    Saga, H
    Yamashita, T
    Tohyama, M
    Shimada, S
    Sato, K
    Sobue, K
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) : 15396 - 15404
  • [5] Mechanical strain increases smooth muscle and decreases nonmuscle myosin expression in rat vascular smooth muscle cells
    Reusch, P
    Wagdy, H
    Reusch, R
    Wilson, E
    Ives, HE
    CIRCULATION RESEARCH, 1996, 79 (05) : 1046 - 1053
  • [6] Sorcin modulation of Ca2+ sparks in rat vascular smooth muscle cells
    Rueda, Angelica
    Song, Ming
    Toro, Ligia
    Stefani, Enrico
    Valdivia, Hector H.
    JOURNAL OF PHYSIOLOGY-LONDON, 2006, 576 (03): : 887 - 901
  • [7] Gene expression of neurotrophins and their receptors in cultured rat vascular smooth muscle cells
    Nemoto, E
    Fukamachi, E
    Nemoto, F
    Miyata, S
    Hamada, M
    Nakamura, Y
    Senba, E
    Ueyama, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 245 (01) : 284 - 288
  • [8] The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells
    Zhu, Dongxing
    Mackenzie, Neil Charles Wallace
    Millan, Jose Luis
    Farquharson, Colin
    MacRae, Vicky Elizabeth
    PLOS ONE, 2011, 6 (05):
  • [9] MODULATION - INDUCED EXPRESSION OF SERUM RESPONSE FACTOR IN VASCULAR SMOOTH-MUSCLE CELLS
    BELKNAP, JK
    SCHWARTZ, PE
    WEISER, MCM
    MAJACK, RA
    JOURNAL OF CELLULAR BIOCHEMISTRY, 1994, : 277 - 277
  • [10] Effects of alpinetin on rat vascular smooth muscle cells
    Li, YJ
    Du, GH
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2004, 6 (02) : 87 - 92
12345