Copper-catalyzed asymmetric ring opening of oxabicyclic alkenes with organolithium reagents

被引：68

作者：

Bos, Pieter H. ^{[1
]}

Rudolph, Alena ^{[1
]}

Perez, Manuel ^{[1
]}

Fananas-Mastral, Martin ^{[1
]}

Harutyunyan, Syuzanna R. ^{[1
]}

Feringa, Ben L. ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

来源：

CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 12期

关键词：

GRIGNARD-REAGENTS; ALKYL HALIDES; STEREOCONTROL; COMPOUND; CARBENES;

D O I：

10.1039/c2cc16855c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient method is reported for the asymmetric ring opening of oxabicyclic alkenes with organolithium reagents. Using a copper/chiral phosphoramidite complex together with a Lewis acid (BF3 center dot OEt2), full selectivity for the anti isomer and excellent enantioselectivities were obtained for the ring opened products.

引用

页码：1748 / 1750

页数：3

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