The Relationship between Serum Uric Acid and Spirometric Values in Participants in a Health Check: The Takahata Study

Background: Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in the production of uric acid (UA). Patients with chronic obstructive pulmonary disease (COPD) have been reported to have high serum levels of UA (sUA), compared with control subjects. However, the relationship between sUA levels and spirometric measures has not been investigated in detail in a general population. Methods: Subjects aged 40 years or older (n = 2,917), who had participated in a community-based annual health check in Takahata, Japan, in 2004 and 2005, were enrolled in the study. These subjects performed spirometry, their blood pressure was measured, and a blood sample was taken. Results: sUA levels were significantly higher in males than in females. Percent predicted forced vital capacity [FVC % predicted] (r = -0.13) and forced expiratory volume in 1 s [FEV(1) % predicted] (r = -0.118) were inversely correlated with sUA levels in females but not in males. Univariate regression analysis indicated that age, body mass index (BMI), ethanol intake, mean blood pressure (BP), and serum creatinine (sCr) were significantly associated with sUA levels in males. In females, age, BMI, mean BP, hemoglobin A1c, sCr, FVC % predicted, and FEV(1) % predicted were significantly associated with sUA levels. Multiple linear regression analysis showed that for both genders, FVC % predicted and FEV(1) % predicted were predictive for sUA levels, independently of the other clinical parameters. Subjects with lung restriction had higher sUA levels than subjects without lung restriction. In addition, subjects with moderate and severe airflow limitation had higher sUA levels than subjects without airflow limitation or those with mild airflow limitation. Conclusion: FVC % predicted and FEV(1) % predicted were significantly associated with sUA levels in a general population.