COX-2 inhibition does not reverse the increased sympathetic modulation in MSG obese rats

被引：9

作者：

da Cunha, Natalia Veronez

Pinge-Filho, Phileno ^{[2
]}

Neto, Octavio Barbosa ^{[3
]}

Grassiolli, Sabrina ^{[4
]}

Martins-Pinge, Marli Cardoso ^{[1
]}

机构：

[1] Univ Estadual Londrina, Dept Physiol Sci, Ctr Ciencias Biol, BR-86055900 Londrina, PR, Brazil

[2] Univ Estadual Londrina, Dept Pathol Sci, BR-86055900 Londrina, PR, Brazil

[3] Univ Fed Triangulo Mineiro, Dept Physiol, Uberaba, MG, Brazil

[4] Univ Estadual Ponta Grossa, Dept Physiol, Ponta Grossa, PR, Brazil

来源：

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2011年 / 165卷 / 02期

关键词：

Spectral analysis; Prostaglandins; Autonomic; Sympathetic; Parasympathetic; Hypertension; OXIDATIVE STRESS; HEART-RATE; HYPERTENSION; VARIABILITY;

D O I：

10.1016/j.autneu.2011.07.006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluate the effects of chronic treatment with celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, on blood pressure (BP) and heart rate variability (HRV) in obese rats induced by neonatal monosodium glutamate (MSG). The animals were treated with celecoxib or saline for 30 days (from the 60th to the 90th day of age). On the 90th day, the MSG obesity induced an increase in the low-frequency (IF) component (CTR = 5.69 +/- 1830 ms(2), MSG = 38.49 +/- 6.27 ms(2)) and a decrease in the high-frequency (HF) component of HRV (CTR = 71.48 +/- 6.22 ms(2), MSG = 50.94 +/- 7.03 ms(2)), which were unchanged by celecoxib treatment. We suggest that HRV in MSG obesity involves a greater sympathetic modulation not related with COX-2 products. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：201 / 204

页数：4

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