Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold

被引：487

作者：

Cavanagh, James F. ^{[1
]}

Wiecki, Thomas V. ^{[1
]}

Cohen, Michael X. ^{[2
,3
]}

Figueroa, Christina M. ^{[1
]}

Samanta, Johan ^{[4
,5
]}

Sherman, Scott J. ^{[4
]}

Frank, Michael J. ^{[1
,6
,7
]}

机构：

[1] Brown Univ, Dept Cognit Linguist & Psychol Sci, Providence, RI 02912 USA

[2] Univ Amsterdam, Dept Psychol, Amsterdam, Netherlands

[3] Univ Arizona, Dept Physiol, Tucson, AZ USA

[4] Univ Arizona, Dept Neurol, Tucson, AZ USA

[5] Banner Good Samaritan Med Ctr, Phoenix, AZ USA

[6] Brown Univ, Dept Psychiat, Providence, RI 02912 USA

[7] Brown Inst Brain Sci, Providence, RI USA

来源：

NATURE NEUROSCIENCE | 2011年 / 14卷 / 11期

关键词：

DEEP BRAIN-STIMULATION; BASAL GANGLIA; PREFRONTAL CORTEX; DYNAMICS; MODEL; SELECTION; HORSES; MONKEY; HOLD;

D O I：

10.1038/nn.2925

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It takes effort and time to tame one's impulses. Although medial prefrontal cortex (mPFC) is broadly implicated in effortful control over behavior, the subthalamic nucleus (STN) is specifically thought to contribute by acting as a brake on cortico-striatal function during decision conflict, buying time until the right decision can be made. Using the drift diffusion model of decision making, we found that trial-to-trial increases in mPFC activity (EEG theta power, 4-8 Hz) were related to an increased threshold for evidence accumulation (decision threshold) as a function of conflict. Deep brain stimulation of the STN in individuals with Parkinson's disease reversed this relationship, resulting in impulsive choice. In addition, intracranial recordings of the STN area revealed increased activity (2.5-5 Hz) during these same high-conflict decisions. Activity in these slow frequency bands may reflect a neural substrate for cortico-basal ganglia communication regulating decision processes.

引用

页码：1462 / U140

页数：8

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