Synthesis of haptens for the development of immunoassays for the monitoring of intracellular anti-HIV nucleosides and nucleotides

被引：15
作者：
Brossette, T
Klein, E
Créminon, C
Grassi, J
Mioskowski, C
Lebeau, L
机构：
[1] Univ Strasbourg 1, Fac Pharm, Associe CNRS, Lab Synthese Bioorgan, F-67401 Illkirch Graffenstaden, France
[2] CEA, Serv Pharmacol & Immunol, Dept Rech Med, F-91191 Gif Sur Yvette, France
来源：
TETRAHEDRON | 2001年 / 57卷 / 38期
关键词：
dideoxynucleoside; HIV; enzyme immunoassay; monophosphate; ddI; d4T; 3TC;
D O I：
10.1016/S0040-4020(01)00800-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of nine modified dideoxynucleosides and dideoxynucleotides has been synthesized for preparing antigenic conjugates with keyhole lympet haemocyanin in order to produce specific antibodies, and develop immunoassays. Derivatives of ddI, ddA, d4T, 3TC, and the corresponding 5 ' -O-monophosphates were designed incorporating an amino spacer at the base for conjugation with the proteinic antigenic carrier. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8129 / 8143
页数：15
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