Asymmetric cooperativity in tandem hybridization of enantiomeric metal complex-tethered short fluorescent DNA probes

被引：21

作者：

Kitamura, Y

Ihara, T

Okada, K

Tsujimura, Y

Shirasaka, Y

Tazaki, M

Jyo, A

机构：

[1] Kumamoto Univ, Dept Appl Chem & Biochem, Kumamoto 8608555, Japan

[2] JST, PRESTO, Kawaguchi, Saitama 3320012, Japan

[3] Sojo Univ, Fac Engn, Kumamoto 8600082, Japan

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 36期

关键词：

D O I：

10.1039/b505632b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The complex [Ru(phen)(2)(dppz)](2+) (phen=1,10-phenanthroline, dppz=dipyrido[3,2-a:2',3'-c]phenazine) was attached to the 5' end of a short oligonucleotide to form conjugates, the Delta-isomer of which showed a high cooperativity during the recognition of the repetitive sequence, while the Lambda-isomer did not.

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页码：4523 / 4525

页数：3

相关论文

共 23 条

[1] STRUCTURE AND FUNCTION OF TELOMERES [J].

BLACKBURN, EH .

NATURE, 1991, 350 (6319) :569-573

[2]

CANTOR CR, 1980, BIOPHYSICAL CHEM, V3, P874

[3] Charge equilibration between two distinct sites in double helical DNA [J].

Delaney, S ;

Yoo, J ;

Stemp, EDA ;

Barton, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (29) :10511-10516

[4] Structural studies of Lambda- and Delta-[Ru(phen)(2)dppz](2+) bound to d(GTCGAC)(2): Characterization of enantioselective intercalation [J].

Dupureur, CM ;

Barton, JK .

INORGANIC CHEMISTRY, 1997, 36 (01) :33-43

[5] BINDING OF DELTA-[RU(PHEN)(3)](2+) AND LAMBDA-[RU(PHEN)(3)](2+) TO [D(CGCGATCGCG)](2) STUDIED BY NMR [J].

ERIKSSON, M ;

LEIJON, M ;

HIORT, C ;

NORDEN, B ;

GRASLUND, A .

BIOCHEMISTRY, 1994, 33 (17) :5031-5040

[6] Recognition and reaction of metallointercalators with DNA [J].

Erkkila, KE ;

Odom, DT ;

Barton, JK .

CHEMICAL REVIEWS, 1999, 99 (09) :2777-2795

[7] Telomerase activity, cell proliferation, and cancer [J].

Greider, CW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) :90-92

[8]

Grimm GN, 2002, CHEMBIOCHEM, V3, P324, DOI 10.1002/1439-7633(20020402)3:4<324::AID-CBIC324>3.0.CO

[9]

2-7

[10] NOVEL DIPYRIDOPHENAZINE COMPLEXES OF RUTHENIUM(II) - EXPLORING LUMINESCENT REPORTERS OF DNA [J].

HARTSHORN, RM ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (15) :5919-5925