Understanding the roles of activation threshold and infections in the dynamics of autoimmune disease

被引：14

作者：

Blyuss, K. B. ^{[1
]}

Nicholson, L. B. ^{[2
,3
]}

机构：

[1] Univ Sussex, Dept Math, Brighton BN1 9QH, E Sussex, England

[2] Univ Bristol, Sch Cellular & Mol Med, Bristol BS8 1TD, Avon, England

[3] Univ Bristol, Sch Clin Sci, Bristol BS8 1TD, Avon, England

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2015年 / 375卷

关键词：

Autoimmunity; Mathematical model; Virus; T-CELL-ACTIVATION; IMMUNOLOGICAL SELF-TOLERANCE; MYELIN BASIC-PROTEIN; MULTIPLE-SCLEROSIS; MOLECULAR MIMICRY; ANTIGEN SENSITIVITY; EFFECTOR FUNCTION; CROSS-REACTIVITY; DENDRITIC CELLS; LCMV INFECTION;

D O I：

10.1016/j.jtbi.2014.08.019

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Onset and development of autoimmunity have been attributed to a number of factors, including genetic predisposition, age and different environmental factors. In this paper we discuss mathematical models of autoimmunity with an emphasis on two particular aspects of immune dynamics: breakdown of immune tolerance in response to an infection with a pathogen, and interactions between T cells with different activation thresholds. We illustrate how the explicit account of T cells with different activation thresholds provides a viable model of immune dynamics able to reproduce several types of immune behaviour, including normal clearance of infection, emergence of a chronic state, and development of a recurrent infection with autoimmunity. We discuss a number of open research problems that can be addressed within the same modelling framework. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：13 / 20

页数：8

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