TLR2 and age-related diseases: Potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction

被引：10

作者：

Balistreri, Carmela Rita ^{[1
]}

Candore, Guiseppina ^{[1
]}

Mirabile, Monica ^{[1
]}

Lio, Domenico ^{[1
]}

Caimi, Gregorio ^{[2
]}

Incalcaterra, Egle ^{[1
,2
]}

Caruso, Marco ^{[2
]}

Hoffmann, Enrico ^{[2
]}

Caruso, Calogero ^{[1
]}

机构：

[1] Univ Palermo, Grp Studio Sull Immunosenescenza, Dipartimento Biopatol & Metodol Biomed, I-90134 Palermo, Italy

[2] Univ Palermo, Dipartimento Med Interna Malattie Cardiovasc & Ne, I-90134 Palermo, Italy

来源：

REJUVENATION RESEARCH | 2008年 / 11卷 / 02期

关键词：

D O I：

10.1089/rej.2008.0666

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Inflammation is a key component of immune system. It is involved in both defense and pathophysiological events maintaining the dynamic homeostasis of host organism. Its function is controlled by innate immunity genes. Both their polymorphisms and environmental conditions give rise to different phenotypes in human population. Proinflammatory genotype may be beneficial in early life but not in old people. With advancing age, indeed, it increases the vulnerability and the intensity to inflammatory reactions responsible for the chronic inflammatory diseases, such as atherosclerosis and myocardial infarction (MI). Several studies have looked for detecting a genetic risk profile that might allow a pharmacogenomic approach to prevent and treat age-related diseases such as MI. We have evaluated the possible association between two polymorphisms of TLR2 gene-Arg677Trp and Arg753Gln-and MI. However, we found no association between TLR2 polymorphisms and MI.

引用

页码：293 / 296

页数：4

共 21 条

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