An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration

被引:4
|
作者
Ranamalla, Saketh Reddy [1 ,2 ]
Porfire, Alina Silvia [1 ]
Tomuta, Ioan [1 ]
Banciu, Manuela [3 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Technol & Bio Pharm, Fac Pharm, Cluj Napoca 400010, Romania
[2] Babes Bolyai Univ, Doctoral Sch Integrat Biol, Fac Biol & Geol, Cluj Napoca 400015, Romania
[3] Babes Bolyai Univ, Dept Mol Biol & Biotechnol, Ctr Syst Biol Biodivers & Bioresources, Cluj Napoca 400015, Romania
关键词
supramolecular; self-assembling; non-covalent interactions; hydrogels; nanofibers; drug delivery; gene delivery; tissue regeneration; HYALURONIC-ACID HYDROGELS; INJECTABLE HYDROGEL; GELATIN HYDROGELS; BUILDING-BLOCKS; PEPTIDE; NANOFIBERS; MEDICINE; INTERNALIZATION; CYCLODEXTRINS; NANOPARTICLES;
D O I
10.3390/pharmaceutics14081733
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tissue regeneration is a prominent area of research, developing biomaterials aimed to be tunable, mechanistic scaffolds that mimic the physiological environment of the tissue. These biomaterials are projected to effectively possess similar chemical and biological properties, while at the same time are required to be safely and quickly degradable in the body once the desired restoration is achieved. Supramolecular systems composed of reversible, non-covalently connected, self-assembly units that respond to biological stimuli and signal cells have efficiently been developed as preferred biomaterials. Their biocompatibility and the ability to engineer the functionality have led to promising results in regenerative therapy. This review was intended to illuminate those who wish to envisage the niche translational research in regenerative therapy by summarizing the various explored types, chemistry, mechanisms, stimuli receptivity, and other advancements of supramolecular systems.
引用
收藏
页数:38
相关论文
共 50 条
  • [21] Two sides to supramolecular drug delivery systems
    Hu, Xiao-Yu
    Wang, Leyong
    SUPRAMOLECULAR CHEMISTRY, 2018, 30 (08) : 664 - 666
  • [22] Supramolecular interaction in the action of drug delivery systems
    Geng, Wen-Chao
    Jiang, Ze-Tao
    Chen, Shi-Lin
    Guo, Dong-Sheng
    CHEMICAL SCIENCE, 2024, 15 (21) : 7811 - 7823
  • [23] Supramolecular Polymer Hydrogels for Drug-Induced Tissue Regeneration
    Cheng, Jing
    Amin, Devang
    Latona, Jessica
    Heber-Katz, Ellen
    Messersmith, Phillip B.
    ACS NANO, 2019, 13 (05) : 5493 - 5501
  • [24] Supramolecular polymer prodrugs for drug-induced tissue regeneration
    Messersmith, Phillip
    Heber-Katz, Ellen
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2019, 258
  • [25] BMP gene delivery for skeletal tissue regeneration
    Bez, Maxim
    Pelled, Gadi
    Gazit, Dan
    BONE, 2020, 137
  • [26] In vitro gene delivery by using supramolecular systems
    Sato, T
    Akino, H
    Nishi, H
    Ishizuka, T
    Ishii, T
    Okahata, Y
    BIOMEDICAL POLYMERS AND POLYMER THERAPEUTICS, 2001, : 397 - 404
  • [27] Supramolecular Polymers Based on Cyclodextrins for Drug and Gene Delivery
    Li, Jia Jing
    Zhao, Feng
    Li, Jun
    BIOFUNCTIONALIZATION OF POLYMERS AND THEIR APPLICATIONS, 2011, 125 : 207 - 249
  • [28] On the Road to Precision Medicine: Magnetic Systems for Tissue Regeneration, Drug Delivery, Imaging, and Theranostics
    Garello, Francesca
    Svenskaya, Yulia
    Parakhonskiy, Bogdan
    Filippi, Miriam
    PHARMACEUTICS, 2023, 15 (07)
  • [29] Progress and Prospects of Polymer-Based Drug Delivery Systems for Bone Tissue Regeneration
    Ogay, Vyacheslav
    Mun, Ellina A.
    Kudaibergen, Gulshakhar
    Baidarbekov, Murat
    Kassymbek, Kuat
    Zharkinbekov, Zharylkasyn
    Saparov, Arman
    POLYMERS, 2020, 12 (12) : 1 - 25
  • [30] RETINOL-CROSSLINKED SUPRAMOLECULAR HYDROGELS FOR TISSUE REGENERATION AND ANTIOXIDANT DELIVERY
    Feliciano, Antonio J.
    Baker, Matthew B.
    Moroni, Lorenzo
    TISSUE ENGINEERING PART A, 2022, 28 : S523 - S523