An Overview of the Supramolecular Systems for Gene and Drug Delivery in Tissue Regeneration

被引:4
|
作者
Ranamalla, Saketh Reddy [1 ,2 ]
Porfire, Alina Silvia [1 ]
Tomuta, Ioan [1 ]
Banciu, Manuela [3 ]
机构
[1] Iuliu Hatieganu Univ Med & Pharm, Dept Pharmaceut Technol & Bio Pharm, Fac Pharm, Cluj Napoca 400010, Romania
[2] Babes Bolyai Univ, Doctoral Sch Integrat Biol, Fac Biol & Geol, Cluj Napoca 400015, Romania
[3] Babes Bolyai Univ, Dept Mol Biol & Biotechnol, Ctr Syst Biol Biodivers & Bioresources, Cluj Napoca 400015, Romania
关键词
supramolecular; self-assembling; non-covalent interactions; hydrogels; nanofibers; drug delivery; gene delivery; tissue regeneration; HYALURONIC-ACID HYDROGELS; INJECTABLE HYDROGEL; GELATIN HYDROGELS; BUILDING-BLOCKS; PEPTIDE; NANOFIBERS; MEDICINE; INTERNALIZATION; CYCLODEXTRINS; NANOPARTICLES;
D O I
10.3390/pharmaceutics14081733
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Tissue regeneration is a prominent area of research, developing biomaterials aimed to be tunable, mechanistic scaffolds that mimic the physiological environment of the tissue. These biomaterials are projected to effectively possess similar chemical and biological properties, while at the same time are required to be safely and quickly degradable in the body once the desired restoration is achieved. Supramolecular systems composed of reversible, non-covalently connected, self-assembly units that respond to biological stimuli and signal cells have efficiently been developed as preferred biomaterials. Their biocompatibility and the ability to engineer the functionality have led to promising results in regenerative therapy. This review was intended to illuminate those who wish to envisage the niche translational research in regenerative therapy by summarizing the various explored types, chemistry, mechanisms, stimuli receptivity, and other advancements of supramolecular systems.
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页数:38
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