A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice

被引：19

作者：

Hofer, M. ^{[1
]}

Pospisil, M. ^{[1
]}

Dusek, L. ^{[2
]}

Hoferova, Z. ^{[1
]}

Weiterova, L. ^{[1
]}

机构：

[1] Acad Sci Czech Republic, Inst Biophys, Lab Expt Hematol, VVI, CZ-61265 Brno, Czech Republic

[2] Masaryk Univ, Inst Biostat & Anal, CZ-62500 Brno, Czech Republic

来源：

RADIATION RESEARCH | 2011年 / 176卷 / 02期

关键词：

GAMMA-IRRADIATION; HEMATOPOIETIC RECOVERY; G-CSF; INDOMETHACIN; TOXICITY;

D O I：

10.1667/RR2614.1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hofer, M., Pospisil, M., Dugek, L., Hoferova, Z. and Weiterova, L. A Single Dose of an Inhibitor of Cyclooxygenase 2, Meloxicam, Administered Shortly after Irradiation Increases Survival of Lethally Irradiated Mice. Radiat. Res. 176, 269-272 (2011). This study extends earlier findings of the authors demonstrating that meloxicam, a selective inhibitor of cyclooxygenase 2, supports hematopoietic recovery in sublethally irradiated mice and is radioprotective when given before irradiation. We report here that when meloxicam was administered in a single dose 1 h after a lethal 9-Gy whole-body dose, an increased 30-day survival was achieved. Additional studies showed that administration of meloxicam 24 h after lethal irradiation is ineffective and its repeated administration deleterious. Possible mechanisms of the therapeutic effects of meloxicam administered early after irradiation are discussed. (C) 2011 by Radiation Research Society

引用

页码：269 / 272

页数：4

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