Transition-Metal-Free Trifluoromethylthiolation of N-Heteroarenes

被引：73

作者：

Honeker, Roman ^{[1
]}

Ernst, Johannes B. ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2015年 / 21卷 / 22期

关键词：

electrophilic substitution; N-heterocycles; sodium chloride; synthetic methods; trifluoromethylthiolation; COPPER-CATALYZED TRIFLUOROMETHYLTHIOLATION; ARYL BORONIC ACIDS; HYPERVALENT IODINE REAGENT; ALPHA-FLUORINATED ETHERS; ELECTROPHILIC TRIFLUOROMETHYLTHIOLATION; NUCLEOPHILIC TRIFLUOROMETHYLTHIOLATION; SELECTIVE TRIFLUOROMETHYLTHIOLATION; OXIDATIVE TRIFLUOROMETHYLTHIOLATION; CONVENIENT SYNTHESIS; CHEMISTRY;

D O I：

10.1002/chem.201500957

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N-heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups.

引用

页码：8047 / 8051

页数：5

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