CRISPR germline engineering-the community speaks

被引：98

作者：

Bosley, Katrine S. ^{[1
]}

Botchan, Michael ^{[2
]}

Bredenoord, Annelien L. ^{[3
]}

Carroll, Dana ^{[4
]}

Charo, R. Alta ^{[5
,6
]}

Charpentier, Emmanuelle ^{[7
]}

Cohen, Ron ^{[8
]}

Corn, Jacob ^{[9
]}

Doudna, Jennifer ^{[10
]}

Feng, Guoping ^{[11
,12
]}

Greely, Henry T. ^{[13
]}

Isasi, Rosario ^{[14
]}

Ji, Weihzi ^{[15
]}

Kim, Jin-Soo ^{[16
,17
]}

Knoppers, Bartha ^{[18
]}

Lanphier, Edward ^{[19
]}

Li, Jinsong ^{[20
]}

Lovell-Badge, Robin ^{[21
]}

Martin, G. Steven ^{[2
]}

Moreno, Jonathan ^{[22
]}

Naldini, Luigi ^{[23
]}

Pera, Martin ^{[24
]}

Perry, Anthony C. F. ^{[25
]}

Venter, J. Craig ^{[26
]}

Zhang, Feng ^{[27
]}

Zhou, Qi ^{[28
]}

机构：

[1] Editas Med, Cambridge, MA 02142 USA

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

[3] Univ Med Ctr, Dept Med Humanities, Utrecht, Netherlands

[4] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT USA

[5] Univ Wisconsin, Sch Law, Madison, WI USA

[6] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Hist & Bioeth, Madison, WI USA

[7] Helmholtz Ctr Infect Res, Dept Regulat Infect Biol, Braunschweig, Germany

[8] Acorda Therapeut, Ardsley, NY USA

[9] Innovat Genom Initiat, Berkeley, CA USA

[10] Univ Calif Berkeley, Dept Mol & Cell Biol & Chem, Berkeley, CA 94720 USA

[11] MIT, Broad Inst, Stanley Ctr Psychiat Res, Dept Brain & Cognit Sci, Cambridge, MA USA

[12] Harvard Univ, Cambridge, MA 02138 USA

[13] Stanford Law Sch, Stanford, CA USA

[14] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[15] Kunming Biomed Int & Natl Engn Res Ctr Biomed & A, Kunming, Peoples R China

[16] Inst for Basic Sci Korea, Ctr Genome Engn, Seoul, South Korea

[17] Seoul Natl Univ, Dept Chem, Seoul, South Korea

[18] McGill Univ, Dept Human Genet, Montreal, PQ, Canada

[19] Sangamo Biosci, Richmond, CA USA

[20] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai, Peoples R China

[21] Francis Crick Inst, London, England

[22] Univ Penn, Philadelphia, PA 19104 USA

[23] San Raffaele Telethon Inst Gene Therapy, Milan, Italy

[24] Univ Melbourne, Dept Anat & Neurosci, Melbourne, Vic, Australia

[25] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England

[26] J Craig Venter Inst, La Jolla, CA USA

[27] MIT & Harvard, Broad Inst, Cambridge, MA USA

[28] Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing, Peoples R China

来源：

NATURE BIOTECHNOLOGY | 2015年 / 33卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nbt.3227

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nature Biotechnology asks selected members of the international community to comment on the ethical issues raised by the prospect of CRISPR-Cas9 engineering of the human germline.

引用

页码：478 / 486

页数：9