Cardiovascular adverse events in multiple myeloma patients

被引：21

作者：

Heckmann, Markus B. ^{[1
,2
]}

Doroudgar, Shirin ^{[1
,2
]}

Katus, Hugo A. ^{[1
,2
]}

Lehmann, Lorenz H. ^{[1
,2
]}

机构：

[1] Univ Hosp Heidelberg, Dept Cardiol Angiol & Pneumol, Internal Med 3, D-69120 Heidelberg, Germany

[2] DZHK German Ctr Cardiovasc Res, Partner Site Heidelberg Mannheim, D-69120 Heidelberg, Germany

来源：

JOURNAL OF THORACIC DISEASE | 2018年 / 10卷

关键词：

Multiple myeloma; cardio-oncology; cardiotoxicity; proteasome inhibitors; carfilzomib; bortezomib; ixazomib; UBIQUITIN-PROTEASOME SYSTEM; RANDOMIZED PHASE-III; CARFILZOMIB-INDUCED CARDIOTOXICITY; NF-KAPPA-B; FUNCTIONAL INSUFFICIENCY; OXIDATIVE STRESS; QUALITY-CONTROL; 2016; ESC; BORTEZOMIB; INHIBITION;

D O I：

10.21037/jtd.2018.09.87

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Multiple myeloma is a malignant disease, caused by an uncontrolled clonal proliferation of a specific group of white blood cells, the plasma cells. Clinical manifestations include bone pain due to osteolysis, hypercalcemia, anemia, and renal insufficiency. Proteasome inhibitors have substantially improved survival of patients suffering from multiple myeloma, providing an efficient treatment option mainly for relapsed and refractory multiple myeloma. Although constituting one substance class, bortezomib, carfilzomib, and ixazomib differ greatly regarding their non-hematologic side effects. This article reviews the clinical and preclinical data on approved proteasome inhibitors in an attempt to decipher the underlying pathomechanisms related to cardiovascular adverse events seen in clinical trials.

引用

页码：S4296 / S4305

页数：10

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