The proteasome

被引：66
作者：
Baumeister, W
Lupas, A
机构：
[1] Max-Planck-Inst. für Biochemie, Department of Structural Biology
来源：
CURRENT OPINION IN STRUCTURAL BIOLOGY | 1997年 / 7卷 / 02期
关键词：
D O I：
10.1016/S0959-440X(97)80036-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The proteasome is a macromolecular assembly that is designed to confine proteolytic activity to an inner cavity. Access to the central proteolytic nanocompartment is restricted to unfolded proteins, which necessitates a functional coupling of the 20S proteasome to a substrate-recognition and unfolding machinery. Significant progress has been made during the past two years in elucidating the structural principles and the enzymatic mechanism of the 20S proteasome.
引用
收藏
页码：273 / 278
页数：6
相关论文
共 52 条
[1]   REPLACEMENT OF PROTEASOME SUBUNIT-X AND SUBUNIT-Y BY LMP7 AND LMP2 INDUCED BY INTERFERON-GAMMA FOR ACQUIREMENT OF THE FUNCTIONAL DIVERSITY RESPONSIBLE FOR ANTIGEN-PROCESSING [J].
AKIYAMA, K ;
KAGAWA, S ;
TAMURA, T ;
SHIMBARA, N ;
TAKASHINA, M ;
KRISTENSEN, P ;
HENDIL, KB ;
TANAKA, K ;
ICHIHARA, A .
FEBS LETTERS, 1994, 343 (01) :85-88
[2]   A PROTEIN CATALYTIC FRAMEWORK WITH AN N-TERMINAL NUCLEOPHILE IS CAPABLE OF SELF-ACTIVATION [J].
BRANNIGAN, JA ;
DODSON, G ;
DUGGLEBY, HJ ;
MOODY, PCE ;
SMITH, JL ;
TOMCHICK, DR ;
MURZIN, AG .
NATURE, 1995, 378 (6555) :416-419
[3]  
BROWN MG, 1993, J IMMUNOL, V151, P1193
[4]   Autocatalytic subunit processing couples active site formation in the 20S proteasome to completion of assembly [J].
Chen, P ;
Hochstrasser, M .
CELL, 1996, 86 (06) :961-972
[5]   BIOGENESIS, STRUCTURE AND FUNCTION OF THE YEAST 20S PROTEASOME [J].
CHEN, P ;
HOCHSTRASSER, M .
EMBO JOURNAL, 1995, 14 (11) :2620-2630
[6]   THE UBIQUITIN-PROTEASOME PROTEOLYTIC PATHWAY [J].
CIECHANOVER, A .
CELL, 1994, 79 (01) :13-21
[7]   PHYLOGENIC RELATIONSHIPS OF THE AMINO-ACID-SEQUENCES OF PROSOME (PROTEASOME, MCP) SUBUNITS [J].
COUX, O ;
NOTHWANG, HG ;
PEREIRA, IS ;
TARGA, FR ;
BEY, F ;
SCHERRER, K .
MOLECULAR & GENERAL GENETICS, 1994, 245 (06) :769-780
[8]   Structure and functions of the 20S and 26S proteasomes [J].
Coux, O ;
Tanaka, K ;
Goldberg, AL .
ANNUAL REVIEW OF BIOCHEMISTRY, 1996, 65 :801-847
[9]   THE MULTICATALYTIC PROTEINASE (PROSOME) IS UBIQUITOUS FROM EUKARYOTES TO ARCHAEBACTERIA [J].
DAHLMANN, B ;
KOPP, F ;
KUEHN, L ;
NIEDEL, B ;
PFEIFER, G ;
HEGERL, R ;
BAUMEISTER, W .
FEBS LETTERS, 1989, 251 (1-2) :125-131
[10]   Identification, purification, and characterization of a PA700-dependent activator of the proteasome [J].
DeMartino, GN ;
Proske, RJ ;
Moomaw, CR ;
Strong, AA ;
Song, XL ;
Hisamatsu, H ;
Tanaka, K ;
Slaughter, CA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (06) :3112-3118
123456