Comparative Analysis of Self-Injury in People with Psychopathology or Neurodevelopmental Disorders

被引：6

作者：

Crapper, Liam ^{[1
,2
]}

Ernst, Carl ^{[1
,2
,3
,4
]}

机构：

[1] McGill Univ, Integrated Program Neurosci, Montreal, PQ H3A 0G4, Canada

[2] Douglas Mental Hlth Univ Inst, McGill Grp Suicide Studies, Montreal, PQ H4H 1R3, Canada

[3] McGill Univ, Dept Psychiat, Montreal, PQ H3A 0G4, Canada

[4] McGill Univ, Dept Human Genet, Montreal, PQ H3A 0G4, Canada

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2015年 / 62卷 / 03期

关键词：

Self-injurious behavior; Neurodevelopmental disorders; Borderline personality disorder; Opioids; Dopamine; LESCH-NYHAN-DISEASE; INTELLECTUAL DISABILITIES; RISK-FACTORS; ENDOGENOUS OPIOIDS; BEHAVIOR PROBLEMS; HPRT DEFICIENCY; YOUNG-CHILDREN; PREVALENCE; DOPAMINE; ADULTS;

D O I：

10.1016/j.pcl.2015.03.001

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Self-injury is a complex and poorly understood behavior observed in people with psychopathology or neurodevelopmental disorders (NDD). Despite the differences in etiology and progression of these distinct disease domains, it is possible that overlapping molecular pathways underlie the expression of self-injurious behaviors (SIBs). This review outlines the similarities and differences at the behavioural and molecular level, where SIBs in both conditions may involve opioid, nucleoside, and dopamine signalling. These points of convergence have important implications for treatment and research of SIB in both populations.

引用

收藏

页码：619 / +

页数：14

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