A Mild and Efficient Protocol for the Protection of 3-Hydroxychromones Under Phase-Transfer Catalysis

被引：9

作者：

Dziuba, Dmytro ^{[1
]}

Benhida, Rachid ^{[1
]}

Burger, Alain ^{[1
]}

机构：

[1] Univ Nice Sophia Antipolis, Inst Chim Nice, CNRS, Lab Chim Mol Bioact & Aromes,UMR 6001, F-06108 Nice 2, France

来源：

SYNTHESIS-STUTTGART | 2011年 / 13期

关键词：

3-hydroxychromone; phase-transfer catalysis; protecting groups; acylation; alkylation; cleavage; INTERMOLECULAR INTERACTIONS; FLUORESCENT; CHROMONES; FLAVONOLS;

D O I：

10.1055/s-0030-1260034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient protocol for the introduction of different protecting groups on 3-hydroxychromones (3-HCs) under phase-transfer catalysis conditions in toluene or dichloromethane/aqueous potassium hydroxide system in the presence of crown ether has been developed. The method is useful for the protection of base-sensitive chromone derivatives. Protected chromones are easier to handle and to purify, and therefore suitable for further chemical transformations. The protecting groups were cleaved cleanly using standard conditions.

引用

页码：2159 / 2164

页数：6

共 28 条

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